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Høyintensitets intervalltrening versus styrketrening for å bedre insulinsensitivitet hos kvinner med polycystisk ovariesyndrom - En randomisert kontrollert studie

Rieber-Mohn, Astrid
Master thesis
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master_01_astrid rieber-mohn.pdf (3.993Mb)
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http://hdl.handle.net/11250/281678
Utgivelsesdato
2014
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  • Institutt for samfunnsmedisin og sykepleie [3385]
Sammendrag
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting

re-productive aged women. PCOS is associated with metabolic complications and an adverse

cardiovascular disease (CVD) profile. Impaired insulin sensitivity is an important factor in the

complex pathophysiology of PCOS. The prevalence of IR is higher in PCOS woman

compared with weight-matched controls. Previous studies have shown a beneficial effect on

IR after aerobic exercise with moderate intensity in women with PCOS. However, limited

knowledge exists on the effect of high intensity interval training and strength training in this

population.

Objectives: The primary aim of the present study was to assess the possible effect of high

intensity interval training (HIT) or strength training (ST) on insulin sensitivity among women

with PCOS compared with a control group (CG). Fasting glucose and insulin c-peptide were

measured as secondary outcomes.

Methods: Thirty-one previously sedentary PCOS women were randomized to one of the

following groups: high intensity interval training (HIT; n=10), strength training (ST; n=11) or

control group (KG; n=10). The intervention period was ten weeks with exercise three times

per week for HIT and ST. Insulin sensitivity calculated as «Homeostasis Model of

Assessment - Insulin Resistance» (HOMA-IR), fasting plasma glucose and insulin c-peptide

were evaluated and compared between groups. The mean changes in each group was reported

as estimated marginal means (EMM), as assessed by 95 % confidence interval (CI) and

considered significant if the 95 % CI did not include zero. Covariance analyses, with

Bonferroni adjustment, were used to test difference between groups, with the difference as the

dependent factor, group variable as the fixed factor, and baseline values as covariates.

Results: Insulin sensitivity (HOMA-IR) was significantly improved by 21 % after HIT

[EMM: -0.30, 95 % CI: -0.45 to -0.15] and by 17 % after ST [EMM: -0.23, 95 % CI: -0.43 to

-0.02], and not in the CG. Fasting insulin c-peptide was reduced after HIT [EMM: - 0.11

nmol/l, 95 % CI: -0.19 to -0.04] and after ST [EMM: -0.11 nmol/l, 95 % CI: -0.20 to -0.02],

and not in the CG. There were no significant changes in plasma glucose level in neither

group. We found no between-group difference in the change in insulin sensitivity (p=0.41) or

insulin c-peptide (p=0.61).

Conclusion: These data indicate that ten weeks of regular HIT and ST have beneficial effect

on insulin sensitivity in women with PCOS.
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