Vis enkel innførsel

dc.contributor.authorOlinski, Ryszard
dc.contributor.authorSlupphaug, Geir
dc.contributor.authorFoksinski, Marek
dc.contributor.authorKrokan, Hans Einar
dc.date.accessioned2021-10-06T12:53:21Z
dc.date.available2021-10-06T12:53:21Z
dc.date.created2021-05-03T09:27:07Z
dc.date.issued2021
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/11250/2788167
dc.description.abstractDNA of all living cells undergoes continuous structural and chemical alterations resulting from fundamental cellular metabolic processes and reactivity of normal cellular metabolites and constituents. Examples include enzymatically oxidized bases, aberrantly methylated bases, and deaminated bases, the latter largely uracil from deaminated cytosine. In addition, the non-canonical DNA base uracil may result from misincorporated dUMP. Furthermore, uracil generated by deamination of cytosine in DNA is not always damage as it is also an intermediate in normal somatic hypermutation (SHM) and class shift recombination (CSR) at the Ig locus of B-cells in adaptive immunity. Many of the modifications alter base-pairing properties and may thus cause replicative and transcriptional mutagenesis. The best known and most studied epigenetic mark in DNA is 5-methylcytosine (5mC), generated by a methyltransferase that uses SAM as methyl donor, usually in CpG contexts. Oxidation products of 5mC are now thought to be intermediates in active demethylation as well as epigenetic marks in their own rights. The aim of this review is to describe the endogenous processes that surround the generation and removal of the most common types of DNA nucleobase modifications, namely, uracil and certain epigenetic modifications, together with their role in the development of hematological malignances. We also discuss what dictates whether the presence of an altered nucleobase is defined as damage or a natural modification.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenomic Uracil and Aberrant Profile of Demethylation Intermediates in Epigenetics and Hematologic Malignanciesen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.volume22en_US
dc.source.journalInternational Journal of Molecular Sciencesen_US
dc.source.issue8en_US
dc.identifier.doi10.3390/ijms22084212
dc.identifier.cristin1907687
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal