| dc.description.abstract | Objective: The purpose of this study was to examine the effects of physical exercise of variable intensity on plasma high-sensitivity cardiac troponin I and T elevation and potential, putative mechanisms, as well as a comparison of used high sensitivity cardiac troponin assays (hs-cTn).
Methods: Twenty-six healthy, physically active participants without known cardiovascular disease completed three bouts of different exercise intensities, including a maximal exercise consumption test (V̇O2max) and an anaerobic threshold (AT) test following a high intensity (80-85% HRmax) session, as well as a moderate intensity (60-70% HRmax) and low intensity (45-55%HRmax) session. All sessions were performed on a treadmill and included a ten-minute warm-up and lasted sixty minutes. Blood samples were taken about ten minutes before and four hours after the exercise. All sessions were at least one week apart. For the blood analysis, the Alinity hs-cTnI assay (Abbott), the ADVIA Centaur hs-cTnI assay (Siemens) and the Roche Cobas 8000 hscTnT assay were used.
Results: Hs-cTnI and hs-cTnT demonstrated significantly elevated values compared to baseline after HIT and MIT. The largest increase in troponin occurred after the HIT session. Fourteen participants showed values above the 99th percentile. All troponin assays significantly correlated with each other at all intensities. No significant correlation between V̇O2max or other parameters were found. MIT caused a higher troponin to increase than LIT, but no values above the 99th percentile were documented after MIT. The troponin elevation after MIT was significantly different to the baseline values which shows a troponin elevation even at lower intensities.
Conclusion: Exercise intensity assessed by heart rate seems to be an independent predictor of cardiac troponin release | |