| dc.description.abstract | Background: High-intensity interval training (HIIT) was previously shown to be a safe strategy to improve cardiorespiratory fitness in certain inflammatory rheumatic diseases (IRDs) in clinical settings. However, it is currently unknown if HIIT combined with maximal strength training (MST) is feasible and effective in a real-world setting. Objective: This study aimed to investigate the effects of combined HIIT and MST on maximal oxygen uptake (V̇O2max), health-related quality of life (HRQoL), and work economy in a population with various IRDs in a therapeutic setting. Methods: In a two-armed randomized controlled trial, 14 patients with IRDs (24-70 years) were assigned to an exercise group (n=8) or a control group (n=6). Both groups received standard medical treatment and in addition, the exercise group performed HIIT and MST three times per week for eight weeks. The primary outcome was V̇O2max. Secondary outcomes were HRQoL measured using the SF-36 questionnaire and work economy. Results: There were no dropouts. Absolute V̇O2max (L.min-1) increased significantly more in the exercise group compared to the control group (p < 0.01). There was an 11.4% increase in absolute V̇O2max in the exercise group (p < 0.05), whereas the control group remained unchanged. The improvement in V̇O2max was accompanied by a 14.1% increase in O2-pulse (p < 0.05) reflecting an increased stroke volume of the heart. The exercise group had significant improvements in the SF-36 domains physical functioning, physical role limitations, fatigue, social functioning, emotional well-being, bodily pain, and general health perception (p < 0.05). All domains except for emotional role limitations changed significantly more in the exercise group compared to the control group (p < 0.05). There were no changes in work economy in any of the groups. Conclusion: Combined HIIT and MST is an effective strategy to improve V̇O2max and HRQoL in IRDs in a real-world setting. No adverse events were reported. Therefore, this type of training may be recommended for patients with IRDs. | |