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dc.contributor.authorØverby, Anders
dc.date.accessioned2015-02-24T08:39:17Z
dc.date.available2015-02-24T08:39:17Z
dc.date.issued2014
dc.identifier.isbn978-82-326-0434-0 (printed ver.)
dc.identifier.isbn978-82-326-0435-7 (electronic ver.)
dc.identifier.issn1503-8181
dc.identifier.urihttp://hdl.handle.net/11250/277286
dc.description.abstractIsothiocyanates are plant phytochemicals produced by Brassicales for protection against herbivores and pathogens. Recent studies have also suggested that these compounds may trigger internal defense responses. However, the cellular events triggered by isothiocyanates in plants remain elusive. In the present thesis, novel cellular mechanisms induced by isothiocyanates in Arabidopsis thaliana are reported, including disintegration of microtubules, attenuation of actin-mediated intracellular transport, depletion of glutathione, induced gene expressions and shift in the cell cycle. Isothiocyanates are also known to have chemopreventive properties against some types of cancer. Gastric cancer is a disease in great need of new treatment modalities. In the present thesis, the effects of isothiocyanates on human gastric cancer cells were studied. The present data shows that isothiocyanates inhibit the cell proliferation and migration, and induce cell cycle arrest and apoptosis in human gastric cancer cells. Moreover, isothiocyanates induce disintegration of microtubules in these cells. Collectively, the findings in this thesis shed light on the emerging field of in vivo role of isothiocyanates in plants, as well as the underlying molecular events of a potent natural therapeutic agent against gastric cancer.nb_NO
dc.language.isoengnb_NO
dc.publisherNTNUnb_NO
dc.relation.ispartofseriesDoctoral thesis at NTNU;
dc.relation.ispartofseries;2014:261
dc.titleFunctional Analysis of the Action of Plant Isothiocyanates: Cellular Mechanisms and In Vivo Role in Plants, and Anticancer Activitynb_NO
dc.typeDoctoral thesisnb_NO
dc.subject.nsiVDP::Mathematics and natural science: 400::Basic biosciences: 470nb_NO


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