The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy
Peer reviewed, Journal article
Published version
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https://hdl.handle.net/11250/2772370Utgivelsesdato
2020Metadata
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Originalversjon
Neuroscience and Biobehavioral Reviews. 2020, 119 422-439. 10.1016/j.neubiorev.2020.09.033Sammendrag
In this review we summarize the connectivity of the nucleus reuniens of the thalamus with the hippocampal region and the prefrontal cortex. Using data from animal studies, complemented with sparse data obtained in humans, we emphasize the relevance of the nucleus reuniens during brain development and in later life, in both epilepsy and schizophrenia. We describe some mechanisms through which RE may contribute to disease development and manifestation, particularly regarding susceptibility for the multitude of well-known genetic and environmental risk factors.