dc.contributor.author | Lecaudey, Laurene Alicia | |
dc.contributor.author | Singh, Pooja | |
dc.contributor.author | Sturmbauer, Christian | |
dc.contributor.author | Dünser, Anna | |
dc.contributor.author | Gessl, Wolfgang | |
dc.contributor.author | Ahi, Ehsan Pashay | |
dc.date.accessioned | 2021-07-06T07:46:13Z | |
dc.date.available | 2021-07-06T07:46:13Z | |
dc.date.created | 2021-07-05T16:36:35Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | BMC Genomics. 2021, 22, . | en_US |
dc.identifier.issn | 1471-2164 | |
dc.identifier.uri | https://hdl.handle.net/11250/2763484 | |
dc.description.abstract | Background
Teleosts display a spectacular diversity of craniofacial adaptations that often mediates ecological specializations. A considerable amount of research has revealed molecular players underlying skeletal craniofacial morphologies, but less is known about soft craniofacial phenotypes. Here we focus on an example of lip hypertrophy in the benthivorous Lake Tangnayika cichlid, Gnathochromis permaxillaris, considered to be a morphological adaptation to extract invertebrates out of the uppermost layer of mud bottom. We investigate the molecular and regulatory basis of lip hypertrophy in G. permaxillaris using a comparative transcriptomic approach.
Results
We identified a gene regulatory network involved in tissue overgrowth and cellular hypertrophy, potentially associated with the formation of a locally restricted hypertrophic lip in a teleost fish species. Of particular interest were the increased expression level of apoda and fhl2, as well as reduced expression of cyp1a, gimap8, lama5 and rasal3, in the hypertrophic lip region which have been implicated in lip formation in other vertebrates. Among the predicted upstream transcription factors, we found reduced expression of foxp1 in the hypertrophic lip region, which is known to act as repressor of cell growth and proliferation, and its function has been associated with hypertrophy of upper lip in human.
Conclusion
Our results provide a genetic foundation for future studies of molecular players shaping soft and exaggerated, but locally restricted, craniofacial morphological changes in fish and perhaps across vertebrates. In the future, we advocate integrating gene regulatory networks of various craniofacial phenotypes to understand how they collectively govern trophic and behavioural adaptations. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Tilpasning til klimaendringer | en_US |
dc.subject | Adaptation | en_US |
dc.subject | Genekspresjon | en_US |
dc.subject | Gene Expression | en_US |
dc.subject | Regulering av genekspresjon | en_US |
dc.subject | Gene Expression Regulation | en_US |
dc.subject | Genregulering | en_US |
dc.subject | Gene regulation | en_US |
dc.subject | RNA | en_US |
dc.subject | RNA | en_US |
dc.title | Transcriptomics unravels molecular players shaping dorsal lip hypertrophy in the vacuum cleaner cichlid, Gnathochromis permaxillaris | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.subject.nsi | VDP::Genetikk og genomikk: 474 | en_US |
dc.subject.nsi | VDP::Genetics and genomics: 474 | en_US |
dc.subject.nsi | VDP::Genetikk og genomikk: 474 | en_US |
dc.subject.nsi | VDP::Genetics and genomics: 474 | en_US |
dc.source.volume | 22 | en_US |
dc.source.journal | BMC Genomics | en_US |
dc.identifier.doi | 10.1186/s12864-021-07775-z | |
dc.identifier.cristin | 1920352 | |
dc.description.localcode | © The Author(s). 2021Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other thirdparty material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visithttp://creativecommons.org/licenses/by/4.0/.The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | en_US |
dc.source.articlenumber | 506 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |