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Mechanics of Porcine Heart Valves’ Strut Chordae Tendineae Investigated as a Leaflet–Chordae–Papillary Muscle Entity

Ross, Colton; Laurence, Devin; Hsu, Ming-Chen; Baumwart, Ryan; Zhao, Yan; Mir, Arshid; Burkhart, Harold; Holzapfel, Gerhard; Wu, Yi; Lee, Chung-Hao
Peer reviewed, Journal article
Published version
Åpne
Ross (Låst)
Permanent lenke
https://hdl.handle.net/11250/2736484
Utgivelsesdato
2020
Metadata
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  • Institutt for konstruksjonsteknikk [1659]
  • Publikasjoner fra CRIStin - NTNU [21987]
Originalversjon
Annals of Biomedical Engineering. 2020, 48 (5), 1463-1474.   10.1007/s10439-020-02464-6
Sammendrag
Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as individual structures, usually in a clamping-based approach, which may not accurately reflect the in vivo chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet–chordae–papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09–1.16, while peak stretches of 1.08–1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.
Utgiver
Springer
Tidsskrift
Annals of Biomedical Engineering

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