Blar i Publikasjoner fra CRIStin - NTNU på tidsskrift "Cell Reports Medicine"
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Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study
(Peer reviewed; Journal article, 2022)Hip fracture is the clinically most important fracture, but the genetic architecture of hip fracture is unclear. Here, we perform a large-scale hip fracture genome-wide association study meta-analysis and Mendelian ... -
Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation
(Peer reviewed; Journal article, 2023)During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is ... -
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
(Peer reviewed; Journal article, 2021)The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity ... -
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
(Peer reviewed; Journal article, 2021)Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), ...