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dc.contributor.authorOlsman, Marieke
dc.contributor.authorSereti, Viktoria
dc.contributor.authorMühlenpfordt, Melina
dc.contributor.authorJohnsen, Kasper Bendix
dc.contributor.authorAndresen, Thomas Lars
dc.contributor.authorUrquhart, Andrew James
dc.contributor.authorDavies, Catharina de Lange
dc.description.abstractThe blood-brain barrier (BBB) is a major obstacle to treating several brain disorders. Focused ultrasound (FUS) in combination with intravascular microbubbles increases BBB permeability by opening tight junctions, creating endothelial cell openings, improving endocytosis and increasing transcytosis. Here we investigated whether combining FUS and microbubbles with transferrin receptor-targeting liposomes would result in enhanced delivery to the brain of post-natal rats compared with liposomes lacking the BBB-targeting moiety. For all animals, increased BBB permeability was observed after FUS treatment. A 40% increase in accumulation of transferrin receptor-targeting liposomes was observed in the FUS-treated hemisphere, whereas the isotype immunoglobulin G liposomes showed no increased accumulation. Confocal laser scanning microscopy of brain sections revealed that both types of liposomes were mainly observed in endothelial cells in the FUS-treated hemisphere. The results demonstrate that FUS and microbubble treatment combined with BBB-targeting liposomes could be a promising approach to enhance drug delivery to the brain. (E-mail: marieke.olsman@ntnu. no)en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleFocused ultrasound and microbubble treatment increases delivery of transferrin receptor-targeting liposomes to the brainen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalUltrasound in Medicine and Biologyen_US
dc.description.localcode© 2021 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology. This is an open access article under the CC BY license (

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal