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dc.contributor.authorWernly, Bernhard
dc.contributor.authorBruno, Raphael Romano
dc.contributor.authorKelm, Malte
dc.contributor.authorBoumendil, Ariane
dc.contributor.authorMorandi, Alessandro
dc.contributor.authorAndersen, Finn Husøy
dc.contributor.authorArtigas, Antonio
dc.contributor.authorFinazzi, Stefano
dc.contributor.authorCecconi, Maurizio
dc.contributor.authorChristensen, Steffen
dc.contributor.authorFaraldi, Loredana
dc.contributor.authorLichtenauer, Michael
dc.contributor.authorMuessig, Johanna M.
dc.contributor.authorMarsh, Brian
dc.contributor.authorMoreno, Rui
dc.contributor.authorOeyen, Sandra
dc.contributor.authorÖhman, Christina Agwald
dc.contributor.authorPinto, Bernadro Bollen
dc.contributor.authorSoliman, Ivo W.
dc.contributor.authorSzczeklik, Wojciech
dc.contributor.authorNiederseer, David
dc.contributor.authorValentin, Andreas
dc.contributor.authorWatson, Ximena
dc.contributor.authorLeaver, Susannah
dc.contributor.authorBoulanger, Carole
dc.contributor.authorWalther, Sten
dc.contributor.authorSchefold, Jörg C.
dc.contributor.authorJoannidis, Michael
dc.contributor.authorNalapko, Yuriy
dc.contributor.authorElhadi, Muhammed
dc.contributor.authorFjølner, Jesper
dc.contributor.authorZafeiridis, Tilemachos
dc.contributor.authorDe Lange, Dylan W.
dc.contributor.authorGuidet, Bertrand
dc.contributor.authorFlaatten, Hans
dc.contributor.authorJung, Christian
dc.date.accessioned2021-02-17T15:17:31Z
dc.date.available2021-02-17T15:17:31Z
dc.date.created2021-01-19T16:34:33Z
dc.date.issued2020
dc.identifier.citationScientific Reports. 2020, 10:18671 1-9.en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2728761
dc.description.abstractFemale and male very elderly intensive patients (VIPs) might differ in characteristics and outcomes. We aimed to compare female versus male VIPs in a large, multinational collective of VIPs with regards to outcome and predictors of mortality. In total, 7555 patients were included in this analysis, 3973 (53%) male and 3582 (47%) female patients. The primary endpoint was 30-day-mortality. Baseline characteristics, data on management and geriatric scores including frailty assessed by Clinical Frailty Scale (CFS) were documented. Two propensity scores (for being male) were obtained for consecutive matching, score 1 for baseline characteristics and score 2 for baseline characteristics and ICU management. Male VIPs were younger (83 ± 5 vs. 84 ± 5; p < 0.001), less often frail (CFS > 4; 38% versus 49%; p < 0.001) but evidenced higher SOFA (7 ± 6 versus 6 ± 6 points; p < 0.001) scores. After propensity score matching, no differences in baseline characteristics could be observed. In the paired analysis, the mortality in male VIPs was higher (mean difference 3.34% 95%CI 0.92–5.76%; p = 0.007) compared to females. In both multivariable logistic regression models correcting for propensity score 1 (aOR 1.15 95%CI 1.03–1.27; p = 0.007) and propensity score 2 (aOR 1.15 95%CI 1.04–1.27; p = 0.007) male sex was independently associated with higher odds for 30-day-mortality. Of note, male gender was not associated with ICU mortality (OR 1.08 95%CI 0.98–1.19; p = 0.14). Outcomes of elderly intensive care patients evidenced independent sex differences. Male sex was associated with adverse 30-day-mortality but not ICU-mortality. Further research to identify potential sex-specific risk factors after ICU discharge is warranted.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleSex-specific outcome disparities in very old patients admitted to intensive care medicine: a propensity matched analysisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-9en_US
dc.source.volume10:18671en_US
dc.source.journalScientific Reportsen_US
dc.identifier.doi10.1038/s41598-020-74910-3
dc.identifier.cristin1874662
dc.description.localcodeOpen Access Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © Te Author(s) 2020en_US
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