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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

dc.contributor.authorHofer, Edith
dc.contributor.authorRoshchupkin, Gennady V.
dc.contributor.authorAdams, Hieab H H
dc.contributor.authorKnol, Maria J.
dc.contributor.authorLin, Honghuang
dc.contributor.authorLi, Shuo
dc.contributor.authorZare, Habil
dc.contributor.authorAhmad, Shahzad
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorPanizzon, Matthew S.
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorDale, Anders M.
dc.contributor.authorLogue, Mark
dc.contributor.authorGrasby, Katrina L.
dc.contributor.authorVan Duijn, Cornelia M.
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorLongstreth, William T.
dc.contributor.authorFornage, Myriam
dc.contributor.authorPaus, Tomas
dc.contributor.authorDebette, Stephanie
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorSchmidt, Helena
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAlmeida, Marcio A.A.
dc.contributor.authorAlnæs, Dag
dc.contributor.authorAmlien, Inge Kasbohm
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorGurholt, Tiril Pedersen
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorRichard, Geneviève
dc.contributor.authorSønderby, Ida Elken
dc.contributor.authorvan der Meer, Dennis
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorBrandt, Christine Lycke
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorKolskår, Knut-Kristian
dc.contributor.authorMelle, Ingrid
dc.contributor.authorNordvik, Jan Egil
dc.contributor.authorSteen, Vidar Martin
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorHåberg, Asta
dc.contributor.authorWright, Margaret J.
dc.contributor.authorZhou, Juan
dc.contributor.authorStein, Jason L.
dc.contributor.authorThompson, Paul M.
dc.contributor.authorMedland, Sarah E.
dc.date.accessioned2021-02-17T15:14:38Z
dc.date.available2021-02-17T15:14:38Z
dc.date.created2021-01-28T10:59:20Z
dc.date.issued2020
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/2728760
dc.description.abstractCortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adultsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.journalNature Communicationsen_US
dc.identifier.doi10.1038/s41467-020-18367-y
dc.identifier.cristin1881070
dc.relation.projectNorges forskningsråd: 223273en_US
dc.description.localcodeOpen Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. © The Author(s) 2020, corrected publication 2021en_US
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