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dc.contributor.authorvan Dorp, Lucy
dc.contributor.authorGelabert, Pere
dc.contributor.authorRieux, Adrien
dc.contributor.authorDe Manuel, Marc
dc.contributor.authorDe-Dios, Toni
dc.contributor.authorGopalakrishnan, Shyam
dc.contributor.authorCarøe, Christian
dc.contributor.authorSandoval-Velasco, Marcela
dc.contributor.authorFregel, Rosa
dc.contributor.authorOlalde, Iñigo
dc.contributor.authorEscosa, Raül
dc.contributor.authorAranda, Carles
dc.contributor.authorHuijben, Silvie
dc.contributor.authorMueller, Ivo
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorBalloux, Francois
dc.contributor.authorGilbert, Marcus Thomas Pius
dc.contributor.authorLalueza-Fox, Carles
dc.identifier.citationMolecular biology and evolution. 2020, 37 (3), 773-785.en_US
dc.description.abstractThe protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonization of the Americas. In addition, we found that some known variants for resistance to antimalarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.en_US
dc.publisherOxford University Pressen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titlePlasmodium vivax Malaria Viewed through the Lens of an Eradicated European Strainen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalMolecular biology and evolutionen_US
dc.description.localcodeThis article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.en_US

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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