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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

dc.contributor.authorSteinthorsdottir, Valgerdur
dc.contributor.authorMcGinnis, Ralph
dc.contributor.authorWilliams, Nicholas O.
dc.contributor.authorStefánsdóttir, Lilja
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorShooter, Scott
dc.contributor.authorFadista, João
dc.contributor.authorSigurdsson, Jon K.
dc.contributor.authorAuro, Kirsi
dc.contributor.authorBerezina, Galina
dc.contributor.authorBorges, Maria-Carolina
dc.contributor.authorBumpstead, Suzannah
dc.contributor.authorBybjerg-Grauholm, Jonas
dc.contributor.authorColgiu, Irina
dc.contributor.authorDolby, Vivien A.
dc.contributor.authorDudbridge, Frank
dc.contributor.authorEngel, Stephanie M.
dc.contributor.authorFranklin, Christopher S.
dc.contributor.authorFrigge, Michael L
dc.contributor.authorFrisbaek, Yr
dc.contributor.authorGeirsson, Reynir T.
dc.contributor.authorGeller, Frank
dc.contributor.authorGretarsdottir, Solveig
dc.contributor.authorGudbjartsson, Daniel F.
dc.contributor.authorHarmon, Quaker
dc.contributor.authorHougaard, David Michael
dc.contributor.authorHegay, Tatyana
dc.contributor.authorHelgadottir, Anna
dc.contributor.authorHjartardóttir, Sigrún
dc.contributor.authorJääskeläinen, Tiina
dc.contributor.authorJohannsdottir, Hrefna
dc.contributor.authorJonsdottir, Ingileif
dc.contributor.authorJuliusdottir, Thorhildur
dc.contributor.authorKalsheker, Noor
dc.contributor.authorKasimov, Abdumadjit
dc.contributor.authorKemp, John P.
dc.contributor.authorKivinen, Katja
dc.contributor.authorKlungsøyr, Kari
dc.contributor.authorLee, Wai K
dc.contributor.authorMelbye, Mads
dc.contributor.authorMiedzybrodska, Zosia
dc.contributor.authorMoffett, Ashley
dc.contributor.authorNajmutdinova, Dilbar
dc.contributor.authorNishanova, Firuza
dc.contributor.authorOlafsdottir, Thorunn
dc.contributor.authorPerola, Markus
dc.contributor.authorPipkin, Fiona Broughton
dc.contributor.authorPoston, Lucilla
dc.contributor.authorPrescott, Gordon
dc.contributor.authorSaevarsdottir, Saedis
dc.contributor.authorSalimbayeva, Damilya
dc.contributor.authorScaife, Paula Juliet
dc.contributor.authorSkotte, Line
dc.contributor.authorStaines-Urias, Eleonora
dc.contributor.authorStefansson, Olafur A.
dc.contributor.authorSørensen, Karina Meden
dc.contributor.authorThomsen, Liv Cecilie Vestrheim
dc.contributor.authorTragante, Vinicius
dc.contributor.authorTrogstad, Lill
dc.contributor.authorSimpson, Nigel A.B.
dc.contributor.authorAripova, Tamara
dc.contributor.authorCasas, Juan P
dc.contributor.authorDominiczak, Anna F
dc.contributor.authorWalker, James J.
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorIversen, Ann-Charlotte
dc.contributor.authorFeenstra, Bjarke
dc.contributor.authorLawlor, Deborah A.
dc.contributor.authorBoyd, Heather Allison
dc.contributor.authorMagnus, Per
dc.contributor.authorLaivuori, Hannele
dc.contributor.authorZakhidova, Nodira
dc.contributor.authorSyvatova, Gulnara
dc.contributor.authorStefansson, Kari
dc.contributor.authorMorgan, Linda
dc.date.accessioned2021-01-08T07:34:57Z
dc.date.available2021-01-08T07:34:57Z
dc.date.created2020-12-16T12:27:15Z
dc.date.issued2020
dc.identifier.citationNature Communications. 2020, 11 1-14.en_US
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/11250/2722109
dc.description.abstractPreeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleGenetic predisposition to hypertension is associated with preeclampsia in European and Central Asian womenen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-14en_US
dc.source.volume11en_US
dc.source.journalNature Communicationsen_US
dc.identifier.doi10.1038/s41467-020-19733-6
dc.identifier.cristin1860515
dc.relation.projectNorges forskningsråd: 223255en_US
dc.description.localcode© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.en_US
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