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dc.contributor.authorEriksen, Anne Marie Høier
dc.contributor.authorNielsen, Tue Kjærgaard
dc.contributor.authorMatthiesen, Henning
dc.contributor.authorCarøe, Christian
dc.contributor.authorHansen, Lars Hestbjerg
dc.contributor.authorGregory, David John
dc.contributor.authorTurner-Walker, Gordon
dc.contributor.authorCollins, Matthew James
dc.contributor.authorGilbert, Marcus Thomas Pius
dc.identifier.citationPLOS ONE. 2020, 15 (10), .en_US
dc.description.abstractBacteria play an important role in the degradation of bone material. However, much remains to be learnt about the structure of their communities in degrading bone, and how the depositional environment influences their diversity throughout the exposure period. We genetically profiled the bacterial community in an experimental series of pig bone fragments (femur and humeri) deposited at different well-defined environments in Denmark. The bacterial community in the bone fragments and surrounding depositional environment were studied over one year, and correlated with the bioerosion damage patterns observed microscopically in the bones. We observed that the bacterial communities within the bones were heavily influenced by the local microbial community, and that the general bone microbial diversity increases with time after exposure. We found the presence of several known collagenase producing bacterial groups, and also observed increases in the relative abundance of several of these in bones with tunneling. We anticipate that future analyses using shotgun metagenomics on this and similar datasets will be able to provide insights into mechanisms of microbiome driven bone degradation.en_US
dc.publisherPublic Library of Scienceen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleBone biodeterioration—The effect of marine and terrestrial depositional environments on early diagenesis and bone bacterial communityen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalPLOS ONEen_US
dc.description.localcode© 2020 Eriksen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US

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