dc.contributor.author | Elvsåshagen, Torbjørn | |
dc.contributor.author | Bahrami, Shahram | |
dc.contributor.author | van der Meer, Dennis | |
dc.contributor.author | Agartz, Ingrid | |
dc.contributor.author | Alnæs, Dag | |
dc.contributor.author | Barch, Deanna M. | |
dc.contributor.author | Baur-Streubel, Ramona | |
dc.contributor.author | Bertolino, Alessandro | |
dc.contributor.author | Beyer, Mona K. | |
dc.contributor.author | Blasi, Giuseppe | |
dc.contributor.author | Borgwardt, Stefan | |
dc.contributor.author | Boye, Birgitte | |
dc.contributor.author | Buitelaar, Jan | |
dc.contributor.author | Bøen, Erlend | |
dc.contributor.author | Celius, Elisabeth Gulowsen | |
dc.contributor.author | Cervenka, Simon | |
dc.contributor.author | Conzelmann, Annette | |
dc.contributor.author | Coynel, David | |
dc.contributor.author | di Carlo, Pasquale | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Eisenacher, Sarah | |
dc.contributor.author | Espeseth, Thomas | |
dc.contributor.author | Fatouros-Bergman, Helena | |
dc.contributor.author | Flyckt, Lena | |
dc.contributor.author | Franke, Barbara | |
dc.contributor.author | Frei, Oleksandr | |
dc.contributor.author | Gelao, Barbara | |
dc.contributor.author | Harbo, Hanne Flinstad | |
dc.contributor.author | Hartman, Catharina A. | |
dc.contributor.author | Håberg, Asta | |
dc.contributor.author | Heslenfeld, Dirk | |
dc.contributor.author | Hoekstra, Pieter J. | |
dc.contributor.author | Høgestøl, Einar August | |
dc.contributor.author | Jonassen, Rune | |
dc.contributor.author | Jönsson, Erik G. | |
dc.contributor.author | Kirsch, Peter | |
dc.contributor.author | Kloszewska, Iwona | |
dc.contributor.author | Lagerberg, Trine Vik | |
dc.contributor.author | Landrø, Nils Inge | |
dc.contributor.author | Le Hellard, Stephanie | |
dc.contributor.author | Lesch, Klaus-Peter | |
dc.contributor.author | Maglanoc, Luigi Angelo | |
dc.contributor.author | Malt, Ulrik Fredrik | |
dc.contributor.author | Mecocci, Patrizia | |
dc.contributor.author | Melle, Ingrid | |
dc.contributor.author | Meyer-Lindenberg, Andreas | |
dc.contributor.author | Moberget, Torgeir | |
dc.contributor.author | Nordvik, Jan Egil | |
dc.contributor.author | Nyberg, Lars | |
dc.contributor.author | O’ Connell, Kevin S. | |
dc.contributor.author | Oosterlaan, Jaap | |
dc.contributor.author | Papalino, Marco | |
dc.contributor.author | Papassotiropoulos, Andreas | |
dc.contributor.author | Pauli, Paul | |
dc.contributor.author | Pergola, Giulio | |
dc.contributor.author | Persson, Karin | |
dc.contributor.author | de Quervain, Dominique | |
dc.contributor.author | Reif, Andreas | |
dc.contributor.author | Rokicki, Jaroslav | |
dc.contributor.author | Van Rooij, Daan | |
dc.contributor.author | Shadrin, Alexey A. | |
dc.contributor.author | Schmidt, André | |
dc.contributor.author | Schwarz, Emanuel | |
dc.contributor.author | Selbæk, Geir | |
dc.contributor.author | Soininen, Hilkka | |
dc.contributor.author | Sowa, Piotr | |
dc.contributor.author | Steen, Vidar M. | |
dc.contributor.author | Tsolaki, Magda | |
dc.contributor.author | Vellas, Bruno | |
dc.contributor.author | Wang, Lei | |
dc.contributor.author | Westman, Eric | |
dc.contributor.author | Ziegler, Georg C. | |
dc.contributor.author | Zink, Mathias | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Westlye, Lars Tjelta | |
dc.contributor.author | Kaufmann, Tobias | |
dc.date.accessioned | 2021-01-05T09:02:20Z | |
dc.date.available | 2021-01-05T09:02:20Z | |
dc.date.created | 2020-12-29T15:00:24Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://hdl.handle.net/11250/2721386 | |
dc.description.abstract | Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The genetic architecture of human brainstem structures and their involvement in common brain disorders | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | Nature Communications | en_US |
dc.identifier.doi | 10.1038/s41467-020-17376-1 | |
dc.identifier.cristin | 1863855 | |
dc.description.localcode | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |