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dc.contributor.authorElvsåshagen, Torbjørn
dc.contributor.authorBahrami, Shahram
dc.contributor.authorvan der Meer, Dennis
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlnæs, Dag
dc.contributor.authorBarch, Deanna M.
dc.contributor.authorBaur-Streubel, Ramona
dc.contributor.authorBertolino, Alessandro
dc.contributor.authorBeyer, Mona K.
dc.contributor.authorBlasi, Giuseppe
dc.contributor.authorBorgwardt, Stefan
dc.contributor.authorBoye, Birgitte
dc.contributor.authorBuitelaar, Jan
dc.contributor.authorBøen, Erlend
dc.contributor.authorCelius, Elisabeth Gulowsen
dc.contributor.authorCervenka, Simon
dc.contributor.authorConzelmann, Annette
dc.contributor.authorCoynel, David
dc.contributor.authordi Carlo, Pasquale
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorEisenacher, Sarah
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFatouros-Bergman, Helena
dc.contributor.authorFlyckt, Lena
dc.contributor.authorFranke, Barbara
dc.contributor.authorFrei, Oleksandr
dc.contributor.authorGelao, Barbara
dc.contributor.authorHarbo, Hanne Flinstad
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHåberg, Asta
dc.contributor.authorHeslenfeld, Dirk
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHøgestøl, Einar August
dc.contributor.authorJonassen, Rune
dc.contributor.authorJönsson, Erik G.
dc.contributor.authorKirsch, Peter
dc.contributor.authorKloszewska, Iwona
dc.contributor.authorLagerberg, Trine Vik
dc.contributor.authorLandrø, Nils Inge
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLesch, Klaus-Peter
dc.contributor.authorMaglanoc, Luigi Angelo
dc.contributor.authorMalt, Ulrik Fredrik
dc.contributor.authorMecocci, Patrizia
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMoberget, Torgeir
dc.contributor.authorNordvik, Jan Egil
dc.contributor.authorNyberg, Lars
dc.contributor.authorO’ Connell, Kevin S.
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorPapalino, Marco
dc.contributor.authorPapassotiropoulos, Andreas
dc.contributor.authorPauli, Paul
dc.contributor.authorPergola, Giulio
dc.contributor.authorPersson, Karin
dc.contributor.authorde Quervain, Dominique
dc.contributor.authorReif, Andreas
dc.contributor.authorRokicki, Jaroslav
dc.contributor.authorVan Rooij, Daan
dc.contributor.authorShadrin, Alexey A.
dc.contributor.authorSchmidt, André
dc.contributor.authorSchwarz, Emanuel
dc.contributor.authorSelbæk, Geir
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorSowa, Piotr
dc.contributor.authorSteen, Vidar M.
dc.contributor.authorTsolaki, Magda
dc.contributor.authorVellas, Bruno
dc.contributor.authorWang, Lei
dc.contributor.authorWestman, Eric
dc.contributor.authorZiegler, Georg C.
dc.contributor.authorZink, Mathias
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorWestlye, Lars Tjelta
dc.contributor.authorKaufmann, Tobias
dc.description.abstractBrainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson’s disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleThe genetic architecture of human brainstem structures and their involvement in common brain disordersen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNature Communicationsen_US
dc.description.localcode© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit licenses/by/4.0/.en_US

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