dc.contributor.author | Palumbo, Fabrizio | |
dc.contributor.author | Serneels, Bram | |
dc.contributor.author | Pelgrims, Robbrecht | |
dc.contributor.author | Yaksi, Emre | |
dc.date.accessioned | 2020-10-19T07:10:27Z | |
dc.date.available | 2020-10-19T07:10:27Z | |
dc.date.created | 2020-09-17T10:47:10Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Cell reports.2020, 32 (8) | en_US |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | https://hdl.handle.net/11250/2683484 | |
dc.description.abstract | Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a changing environment. We show that juvenile zebrafish can perform conditioned place avoidance learning, with improving performance across development. Ablation of the dorsolateral habenula (dlHb), a brain region involved in associative learning and prediction of outcomes, leads to an unexpected improvement in performance and delayed memory extinction. Interestingly, the control animals exhibit rapid adaptation to a changing learning rule, whereas dlHb-ablated animals fail to adapt. Altogether, our results show that the dlHb plays a central role in switching animals’ strategies while integrating new evidence with prior experience. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Zebrafish dorsal habenula is required for updating learned behaviors | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 32 | en_US |
dc.source.journal | Cell reports | en_US |
dc.source.issue | 8 | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2020.108054 | |
dc.identifier.cristin | 1830738 | |
dc.description.localcode | This article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |