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dc.contributor.authorVietri, Marina
dc.contributor.authorRadulovic, Maja
dc.contributor.authorStenmark, Harald
dc.date.accessioned2020-09-03T11:17:56Z
dc.date.available2020-09-03T11:17:56Z
dc.date.created2019-12-03T12:14:00Z
dc.date.issued2019
dc.identifier.citationNature reviews. Molecular cell biology. 2019, 21 25-42.en_US
dc.identifier.issn1471-0072
dc.identifier.urihttps://hdl.handle.net/11250/2676208
dc.description.abstractCellular membranes can form two principally different involutions, which either exclude or contain cytosol. The ‘classical’ budding reactions, such as those occurring during endocytosis or formation of exocytic vesicles, involve proteins that assemble on the cytosol-excluding face of the bud neck. Inverse membrane involution occurs in a wide range of cellular processes, supporting cytokinesis, endosome maturation, autophagy, membrane repair and many other processes. Such inverse membrane remodelling is mediated by a heteromultimeric protein machinery known as endosomal sorting complex required for transport (ESCRT). ESCRT proteins assemble on the cytosolic (or nucleoplasmic) face of the neck of the forming involution and cooperate with the ATPase VPS4 to drive membrane scission or sealing. Here, we review similarities and differences of various ESCRT-dependent processes, with special emphasis on mechanisms of ESCRT recruitment.en_US
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.titleThe many functions of ESCRTsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber25-42en_US
dc.source.volume21en_US
dc.source.journalNature reviews. Molecular cell biologyen_US
dc.identifier.doi10.1038/s41580-019-0177-4
dc.identifier.cristin1755992
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2020 by Nature Research.en_US
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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