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dc.contributor.authorNASBO, NASBO Collaborators
dc.contributor.authorBolkan, Håkon Angell
dc.date.accessioned2020-08-28T11:48:17Z
dc.date.available2020-08-28T11:48:17Z
dc.date.created2020-01-15T08:31:10Z
dc.date.issued2019
dc.identifier.citationEuropean Journal of Surgical Oncology. 2019, 45 2319-2324.en_US
dc.identifier.issn0748-7983
dc.identifier.urihttps://hdl.handle.net/11250/2675541
dc.description.abstractIntroduction Patients with cancer who develop small bowel obstruction are at high risk of malnutrition and morbidity following compromise of gastrointestinal tract continuity. This study aimed to characterise current management and outcomes following malignant small bowel obstruction. Methods A prospective, multicentre cohort study of patients with small bowel obstruction who presented to UK hospitals between 16th January and 13th March 2017. Patients who presented with small bowel obstruction due to primary tumours of the intestine (excluding left-sided colonic tumours) or disseminated intra-abdominal malignancy were included. Outcomes included 30-day mortality and in-hospital complications. Cox-proportional hazards models were used to generate adjusted effects estimates, which are presented as hazard ratios (HR) alongside the corresponding 95% confidence interval (95% CI). The threshold for statistical significance was set at the level of P ≤ 0.05 a-priori. Results 205 patients with malignant small bowel obstruction presented to emergency surgery services during the study period. Of these patients, 50 had obstruction due to right sided colon cancer, 143 due to disseminated intraabdominal malignancy, 10 had primary tumours of the small bowel and 2 patients had gastrointestinal stromal tumours. In total 100 out of 205 patients underwent a surgical intervention for obstruction. 30-day in-hospital mortality rate was 11.3% for those with primary tumours and 19.6% for those with disseminated malignancy. Severe risk of malnutrition was an independent predictor for poor mortality in this cohort (adjusted HR 16.18, 95% CI 1.86 to 140.84, p = 0.012). Patients with right-sided colon cancer had high rates of morbidity. Conclusions Mortality rates were high in patients with disseminated malignancy and in those with right sided colon cancer. Further research should identify optimal management strategy to reduce morbidity for these patient groups.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.titleOutcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction.en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber2319-2324en_US
dc.source.volume45en_US
dc.source.journalEuropean Journal of Surgical Oncologyen_US
dc.identifier.doi10.1016/j.ejso.2019.07.014
dc.identifier.cristin1773259
dc.description.localcodeThis article will not be available due to copyright restrictions (c) 2019 by Elsevier.en_US
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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