dc.contributor.author | Zhi, Xiaofei | |
dc.contributor.author | Jiang, Baofei | |
dc.contributor.author | Yu, Junbo | |
dc.contributor.author | Røe, Oluf Dimitri | |
dc.contributor.author | Qin, Jun | |
dc.contributor.author | Ni, Qingfeng | |
dc.contributor.author | Sun, Luning | |
dc.contributor.author | Xu, Meirong | |
dc.contributor.author | Zhu, Jianwei | |
dc.contributor.author | Ma, Lilin | |
dc.date.accessioned | 2020-04-29T12:44:22Z | |
dc.date.available | 2020-04-29T12:44:22Z | |
dc.date.created | 2016-11-10T16:07:28Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Scientific Reports. 2016, 6 (21541) | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/11250/2652949 | |
dc.description.abstract | The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival (DFS) and overall survival (OS) in patients with primary GISTs. Twelve studies with 1985 GIST patients were included. The overall recurrence rate in R1 resection and R0 resection group was 0.364 (95% CI 0.299–0.429) and 0.296 (95% CI 0.161–0.430), respectively. Meta-analysis confirmed that a microscopically positive margin could significantly impact the disease-free survival (HR 1.596, 95% CI 1.128–2.258; I2 = 37.5%, P value = 0.091), but had no influence on overall survival (HR 1.430, 95% CI 0.608–3.363; I2 = 60.8%, P value = 0.013). Importantly, subgroup analysis revealed that adjuvant imatinib treatment could attenuate the risk of recurrence for primary GIST patients who received R1 resection. (HR 1.308, 95% CI 0.583–2.935; I2 = 53.2%, P value = 0.074). The level of evidence achieved in this study was “moderate” for DFS and “low” for OS. In conclusion, this study revealed that a microscopically positive margin is an unfavorable prognostic factor for GIST patients with R1 resection and adjuvant imatinib treatment is proved to be effective. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 6 | en_US |
dc.source.journal | Scientific Reports | en_US |
dc.identifier.doi | 10.1038/srep21541 | |
dc.identifier.cristin | 1399285 | |
dc.description.localcode | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |