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dc.contributor.authorMitchell, Jonathan S
dc.contributor.authorLi, Ni
dc.contributor.authorWeinhold, Niels
dc.contributor.authorFörsti, Asta
dc.contributor.authorAli, Mina
dc.contributor.authorVan Duin, Mark
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorJohnson, David C
dc.contributor.authorChen, Bowang
dc.contributor.authorHalvarsson, Britt-Marie
dc.contributor.authorGudbjartsson, Daniel F.
dc.contributor.authorKuiper, Rowan
dc.contributor.authorStephens, Owen W
dc.contributor.authorBertsch, Uta
dc.contributor.authorBroderick, Peter
dc.contributor.authorCampo, Chiara
dc.contributor.authorEinsele, Hermann
dc.contributor.authorGregory, Walter A
dc.contributor.authorGullberg, Urban
dc.contributor.authorHenrion, Marc
dc.contributor.authorHillengass, Jens
dc.contributor.authorHoffmann, Per
dc.contributor.authorJackson, Graham H.
dc.contributor.authorJohnsson, Ellinor
dc.contributor.authorJöud, Magnus
dc.contributor.authorKristinsson, Sigurdur Y
dc.contributor.authorLenhoff, Stig
dc.contributor.authorLenive, Oleg
dc.contributor.authorMellqvist, Ulf-Henrik
dc.contributor.authorMigliorini, Gabriele
dc.contributor.authorNahi, Hareth
dc.contributor.authorNelander, Sven
dc.contributor.authorNickel, Jolanta
dc.contributor.authorNothen, Markus M
dc.contributor.authorRafnar, Thorunn
dc.contributor.authorRoss, Fiona M
dc.contributor.authorDa Silva Filho, Miguel Inacio
dc.contributor.authorSwaminathan, Bhairavi
dc.contributor.authorThomsen, Hauke
dc.contributor.authorTuresson, Ingemar
dc.contributor.authorVangsted, Annette
dc.contributor.authorVogel, Ulla
dc.contributor.authorWaage, Anders
dc.contributor.authorWalker, Brian A
dc.contributor.authorWihlborg, Anna-Karin
dc.contributor.authorBroyl, Annemiek
dc.contributor.authorDavies, Faith E
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorLanger, Christian
dc.contributor.authorHansson, Markus
dc.contributor.authorKaiser, Martin
dc.contributor.authorSonneveld, Pieter
dc.contributor.authorStefansson, Kari
dc.contributor.authorMorgan, Gareth J
dc.contributor.authorGoldschmidt, Hartmut
dc.contributor.authorHemminki, Kari
dc.contributor.authorNilsson, Björn
dc.contributor.authorHoulston, Richard S.
dc.identifier.citationNature Communications. 2016, 7en_US
dc.description.abstractMultiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10−8), 6q21 (rs9372120, P=9.09 × 10−15), 7q36.1 (rs7781265, P=9.71 × 10−9), 8q24.21 (rs1948915, P=4.20 × 10−11), 9p21.3 (rs2811710, P=1.72 × 10−13), 10p12.1 (rs2790457, P=1.77 × 10−8), 16q23.1 (rs7193541, P=5.00 × 10−12) and 20q13.13 (rs6066835, P=1.36 × 10−13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.en_US
dc.publisherNature Researchen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleGenome-wide association study identifies multiple susceptibility loci for multiple myelomaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNature Communicationsen_US
dc.description.localcodeThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal