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dc.contributor.authorJohns, Neil
dc.contributor.authorStretch, C
dc.contributor.authorTan, BH
dc.contributor.authorSolheim, Tora Skeidsvoll
dc.contributor.authorSørhaug, Sveinung
dc.contributor.authorStephens, NA
dc.contributor.authorGioulbasanis, Ioannis
dc.contributor.authorSkipworth, RJ
dc.contributor.authorDeans, DA
dc.contributor.authorVigano, Antonio A.L.
dc.contributor.authorRoss, JA
dc.contributor.authorBathe, OF
dc.contributor.authorTremblay, ML
dc.contributor.authorKaasa, Stein
dc.contributor.authorStrasser, Florian
dc.contributor.authorGagnon, B
dc.contributor.authorBaracos, VE
dc.contributor.authorDamaraju, S
dc.contributor.authorFearon, KC
dc.identifier.citationJournal of Cachexia, Sarcopenia and Muscle. 2017, 8 (1), 122-130.en_US
dc.description.abstractBackground Cachexia affects the majority with advanced cancer. Based on current demographic and clinical factors, it is not possible to predict who will develop cachexia or not. Such variation may, in part, be due to genotype. It has recently been proposed to extend the diagnostic criteria for cachexia to include a direct measure of low skeletal muscle index (LSMI) in addition to weight loss (WL). We aimed to explore our panel of candidate single nucleotide polymorphism (SNPs) for association with WL +/− computerized tomography‐defined LSMI. We also explored whether the transcription in muscle of identified genes was altered according to such cachexia phenotype Methods A retrospective cohort study design was used. Analysis explored associations of candidate SNPs with WL (n = 1276) and WL + LSMI (n = 943). Human muscle transcriptome (n = 134) was analysed using an Agilent platform. Results Single nucleotide polymorphisms in the following genes showed association with WL alone: GCKR, LEPR, SELP, ACVR2B, TLR4, FOXO3, IGF1, CPN1, APOE, FOXO1, and GHRL. SNPs in LEPR, ACVR2B, TNF, and ACE were associated with concurrent WL + LSMI. There was concordance between muscle‐specific expression for ACVR2B, FOXO1 and 3, LEPR, GCKR, and TLR4 genes and LSMI and/or WL (P < 0.05). Conclusions The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI. These findings focus attention on pro‐inflammatory cytokines and the renin–angiotensin system as biomarkers/mediators of muscle wasting in cachexia.en_US
dc.publisherohn Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.en_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleNew genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalJournal of Cachexia, Sarcopenia and Muscleen_US
dc.description.localcodeThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal