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dc.contributor.authorZuo, Hui
dc.contributor.authorUeland, Per Magne
dc.contributor.authorMidttun, Øivind
dc.contributor.authorTell, Grethe S.
dc.contributor.authorFanidi, Anouar
dc.contributor.authorZheng, Wei
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorWu, Jie
dc.contributor.authorPrentice, Ross L.
dc.contributor.authorPettinger, Mary
dc.contributor.authorThomson, Cynthia A.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorHodge, Allison M.
dc.contributor.authorCai, Qiuyin
dc.contributor.authorBlot, William J.
dc.contributor.authorJohansson, Mikael B.
dc.contributor.authorHultdin, Johan
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorMcCullough, Marjorie L.
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorZiegler, Regina G.
dc.contributor.authorFreedman, Neal David
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorHveem, Kristian
dc.contributor.authorNæss, Marit
dc.contributor.authorBuring, Julie E.
dc.contributor.authorLee, I-Min
dc.contributor.authorGaziano, John Michael
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorZhang, Xuehong
dc.contributor.authorStampfer, Meir Jonathan
dc.contributor.authorHan, Jiali
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorMarchand, Loïc Le
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorWang, Renwei
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorGao, Yutang
dc.contributor.authorEricson, Ulrika C.
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorJones, Michael R.
dc.contributor.authorRelton, Caroline Laura
dc.contributor.authorBrennan, Paul J.
dc.contributor.authorJohansson, Mattias
dc.contributor.authorUlvik, Arve
dc.identifier.citationAnnals of Oncology. 2019, 30 (3), 478-485.nb_NO
dc.description.abstractBackground Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods For this study, we included 5323 incident lung cancer cases and 5323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium. Cohort-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between PAr and lung cancer risk were calculated using conditional logistic regression and pooled using random-effects models. Results PAr was positively associated with lung cancer risk in a dose-response fashion. Comparing the fourth versus first quartiles of PAr resulted in an OR of 1.38 (95% CI: 1.19–1.59) for overall lung cancer risk. The association between PAr and lung cancer risk was most prominent in former smokers (OR: 1.69, 95% CI: 1.36–2.10), men (OR: 1.60, 95% CI: 1.28–2.00), and for cancers diagnosed within 3 years of blood draw (OR: 1.73, 95% CI: 1.34–2.23). Conclusion Based on pre-diagnostic data from 20 cohorts across 4 continents, this study confirms that increased vitamin B6 catabolism related to inflammation and immune activation is associated with a higher risk of developing lung cancer. Moreover, PAr may be a pre-diagnostic marker of lung cancer rather than a causal factor.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleVitamin B6 catabolism and lung cancer risk: Results from the Lung Cancer Cohort Consortium (LC3)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalAnnals of Oncologynb_NO
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015nb_NO
dc.description.localcode(c) The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. Annals of Oncology 30: 478–485, 2019 doi:10.1093/annonc/mdz002 Published online 30 January 2019 This is an Open Access article under the CC-BY-NC-ND license.nb_NO
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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