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dc.contributor.authorWildisen, Lea
dc.contributor.authorMoutzouri, Elisavet
dc.contributor.authorBeglinger, Shanthi
dc.contributor.authorSyrogiannouli, Lamprini
dc.contributor.authorCappola, Anne R.
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorBakker, Stephan JL
dc.contributor.authorCeresini, Graziano
dc.contributor.authorDullaart, Robin P.F.
dc.contributor.authorFerrucci, Luigi
dc.contributor.authorGrabe, Hans
dc.contributor.authorJukema, J Wouter
dc.contributor.authorNauck, Matthias
dc.contributor.authorTrompet, Stella
dc.contributor.authorVölzke, Henry
dc.contributor.authorWestendorp, Rudi G.J.
dc.contributor.authorGussekloo, Jacobijn
dc.contributor.authorPeeters, Robin P.
dc.contributor.authorKloppel, Stefan
dc.contributor.authorAujesky, Drahomir
dc.contributor.authorBauer, Douglas C.
dc.contributor.authorRodondi, Nicolas
dc.contributor.authorDel Giovane, Cinzia
dc.contributor.authorFeller, Martin
dc.identifier.citationBMJ Open. 2019, 9 (7), e029716-?.nb_NO
dc.description.abstractIntroductionProspective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating hormone cut-off levels or degree of baseline depressive symptoms. Analysis of individual participant data (IPD) may help clarify this association.Methods and analysis: We will conduct a systematic review and IPD meta-analysis of prospective studies on the association between subclinical thyroid dysfunction and depressive symptoms. We will identify studies through a systematic search of the literature in the Ovid Medline, Ovid Embase, Cochrane Central Register of Controlled Trials (CENTRAL) and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases from inception to April 2019 and from the Thyroid Studies Collaboration. We will ask corresponding authors of studies that meet our inclusion criteria to collaborate by providing IPD. Our primary outcome will be depressive symptoms at the first available individual follow-up, measured on a validated scale. We will convert all the scores to the Beck Depression Inventory scale. For each cohort, we will estimate the mean difference of depressive symptoms between participants with subclinical hypothyroidism or hyperthyroidism and control adjusted for depressive symptoms at baseline. Furthermore, we will adjust our multivariable linear regression analyses for age, sex, education and income. We will pool the effect estimates of all studies in a random-effects meta-analysis. Heterogeneity will be assessed by I2. Our secondary outcomes will be depressive symptoms at a specific follow-up time, at the last available individual follow-up and incidence of depression at the first, last and at a specific follow-up time. For the binary outcome of incident depression, we will use a logistic regression model.Ethics and disseminationFormal ethical approval is not required as primary data will not be collected. Our findings will have considerable implications for patient care. We will seek to publish this systematic review and IPD meta-analysis in a high-impact clinical journalnb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleSubclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studiesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMJ Opennb_NO
dc.description.localcodeThis is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.unitnameMedisinsk klinikk

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Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal