Drug prescription patterns in elderly hip fracture patients at admission and discharge from hospital: A substudy of the Trondheim Hip Fracture Trial - a randomized controlled trial
MetadataShow full item record
Background: Hip fractures in the elderly are common, and may have serious consequences. Drug use might be contributing to the falls and subsequent fractures, and might be of significance as an intervention target. The present study was a substudy of the Trondheim Hip Fracture Trial, a study where hip fracture patients were randomly assigned to Comprehensive Geriatric Assessment (CGA) as part of Comprehensive Geriatric Care (CGC) in an orthogeriatric unit or standard orthopedic care (OC) in the Orthopedic Ward. Objective: To investigate drug use in older hip fracture patients treated with CGC as compared to OC with emphasis on polypharmacy, cardiovascular, CNS-affecting and anticholinergic drugs, and treatment for osteoporosis, pain and constipation at admission and discharge from hospital,. Methods: The participants were 397 home-dwelling older persons >70 years of age. Information on drug regimen at admission and discharge were collected retrospectively and the drug profile analyzed with regard to polypharmacy, cardiovascular, CNS-affecting and anticholinergic drugs, and treatment for osteoporosis, pain and constipation at admission and discharge from hospital. Results: More patients were found to have polypharmacy at discharge in the CGC group. When excluding preventive and limited duration drugs no difference between the groups were found. More patients in the CGC group received osteoporosis and constipation preventing drugs at discharge, and more patients had a scheduled pain regimen. There were more changes done to cardiovascular and psychotropic drugs in the CGC. Conclusions: There were more polypharmacy with polypharmacy overall in the CGC groups at discharge, the difference was mainly related to more prescriptions for constipation, pain and osteoporosis. More changes were done during the hospital stay in the CGC group.