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dc.contributor.authorMikalsen, Solveig Meyer
dc.contributor.authorBjørke-Monsen, Anne Lise
dc.contributor.authorFlaten, Trond Peder
dc.contributor.authorWhist, Jon Elling
dc.contributor.authorAaseth, Jan
dc.date.accessioned2020-01-15T09:47:45Z
dc.date.available2020-01-15T09:47:45Z
dc.date.created2019-06-18T13:28:09Z
dc.date.issued2019
dc.identifier.citationJournal of Trace Elements in Medicine and Biology. 2019, 54, 150-155.nb_NO
dc.identifier.issn0946-672X
dc.identifier.urihttp://hdl.handle.net/11250/2636359
dc.description.abstractPurpose Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after bariatric surgery and weight loss. As about 80% of patients undergoing bariatric surgery are women, most of them of childbearing age, there are concerns regarding fetal exposure to toxic trace elements. We measured whole blood Hg, Pb and Cd concentrations in morbidly obese patients before and 12 months after Roux-en-Y gastric bypass (RYGB). Patients and methods Forty-six patients eligible for bariatric surgery were recruited at Innlandet Hospital Trust, Norway (2012–2014). The majority were women and 54% were of reproductive age. Whole blood samples were collected prior to and 12 months after surgery. Trace element concentrations were measured using mass spectrometry (HR-ICP-MS). Results Median whole blood Pb concentrations increased by 73% during the 12 months study period while Hg and Cd decreased by 31% and 27%, respectively. We found a negative correlation between Pb levels before surgery and BMI (p = 0.02). Before surgery patients with hypertension had significantly higher median whole blood Hg levels compared to patients with normal blood pressure (p < 0.001). Conclusion One year after bariatric surgery, the median whole blood Pb concentration was increased, while Hg and Cd concentrations were decreased. The majority of bariatric surgery patients are women of reproductive age and weight loss is associated with improved fertility. As even low dose Pb exposure during fetal life is associated with negative effects on the central nervous system, the observed increase in whole blood Pb after weight loss causes concern. Further studies are needed to elucidate these observations.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.relation.urihttps://pdf.sciencedirectassets.com/273208/1-s2.0-S0946672X19X00036/1-s2.0-S0946672X19301804/main.pdf?X-Amz-Date=20190823T074653Z&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Signature=0c867a4df905e2da6134e
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleCadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgerynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber150-155nb_NO
dc.source.volume54nb_NO
dc.source.journalJournal of Trace Elements in Medicine and Biologynb_NO
dc.identifier.doi10.1016/j.jtemb.2019.04.008
dc.identifier.cristin1705706
dc.description.localcode© 2019 The Authors. Published by Elsevier GmbH. his article is available under the Creative Commons CC-BY-NC-ND license and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. For commercial reuse, permission must be requested.nb_NO
cristin.unitcode194,66,25,0
cristin.unitnameInstitutt for kjemi
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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