dc.contributor.author | Creese, Byron | |
dc.contributor.author | Vassos, Evangelos | |
dc.contributor.author | Bergh, Sverre | |
dc.contributor.author | Athanasiu, Lavinia | |
dc.contributor.author | Johar, Iskandar | |
dc.contributor.author | Rongve, Arvid | |
dc.contributor.author | Medbøen, Ingrid Tøndel | |
dc.contributor.author | Da Silva, Miguel Vasconcelos | |
dc.contributor.author | Aakhus, Eivind | |
dc.contributor.author | Andersen, Fred | |
dc.contributor.author | Bettella, Francesco | |
dc.contributor.author | Brækhus, Anne | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Paroni, Giulia | |
dc.contributor.author | Proitsi, Petroula | |
dc.contributor.author | Saltvedt, Ingvild | |
dc.contributor.author | Seripa, Davide | |
dc.contributor.author | Stordal, Eystein | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Ballard, Clive | |
dc.contributor.author | Selbæk, Geir | |
dc.date.accessioned | 2019-12-16T12:33:20Z | |
dc.date.available | 2019-12-16T12:33:20Z | |
dc.date.created | 2019-10-29T09:29:47Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Translational psychiatry. 2019, 9:273 1-10. | nb_NO |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | http://hdl.handle.net/11250/2633413 | |
dc.description.abstract | Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-10 | nb_NO |
dc.source.volume | 9:273 | nb_NO |
dc.source.journal | Translational psychiatry | nb_NO |
dc.identifier.doi | 10.1038/s41398-019-0592-5 | |
dc.identifier.cristin | 1741516 | |
dc.description.localcode | © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | nb_NO |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 1920,15,0,0 | |
cristin.unitcode | 194,65,35,0 | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | Medisinsk klinikk | |
cristin.unitname | Institutt for psykisk helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |