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dc.contributor.authorCreese, Byron
dc.contributor.authorVassos, Evangelos
dc.contributor.authorBergh, Sverre
dc.contributor.authorAthanasiu, Lavinia
dc.contributor.authorJohar, Iskandar
dc.contributor.authorRongve, Arvid
dc.contributor.authorMedbøen, Ingrid Tøndel
dc.contributor.authorDa Silva, Miguel Vasconcelos
dc.contributor.authorAakhus, Eivind
dc.contributor.authorAndersen, Fred
dc.contributor.authorBettella, Francesco
dc.contributor.authorBrækhus, Anne
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorParoni, Giulia
dc.contributor.authorProitsi, Petroula
dc.contributor.authorSaltvedt, Ingvild
dc.contributor.authorSeripa, Davide
dc.contributor.authorStordal, Eystein
dc.contributor.authorFladby, Tormod
dc.contributor.authorAarsland, Dag
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorBallard, Clive
dc.contributor.authorSelbæk, Geir
dc.identifier.citationTranslational psychiatry. 2019, 9:273 1-10.nb_NO
dc.description.abstractPsychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleExamining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's diseasenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalTranslational psychiatrynb_NO
dc.description.localcode© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameMedisinsk klinikk
cristin.unitnameInstitutt for psykisk helse

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal