dc.contributor.author | Kvehaugen, Anne Stine | |
dc.contributor.author | Melien, Øyvind | |
dc.contributor.author | Holmen, Oddgeir | |
dc.contributor.author | Laivuori, Hannele | |
dc.contributor.author | Dechend, Ralf | |
dc.contributor.author | Staff, Anne Cathrine | |
dc.date.accessioned | 2019-11-08T07:41:48Z | |
dc.date.available | 2019-11-08T07:41:48Z | |
dc.date.created | 2014-10-30T08:57:07Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | BMC Medical Genetics. 2014, 15 (28), . | nb_NO |
dc.identifier.issn | 1471-2350 | |
dc.identifier.uri | http://hdl.handle.net/11250/2627274 | |
dc.description.abstract | Background
Preeclampsia is associated with an increased risk of hypertension later in life. The regulator of G protein signaling 2 negatively regulates several vasoconstrictors. We recently demonstrated an association between preeclampsia and the CG or GG genotype of the C1114G polymorphism (rs4606) of the regulator of G protein signaling 2 gene. Here, we examined the polymorphism with respect to the development of hypertension after pregnancy.
Methods
We genotyped 934 women on average 15.1 years after preeclampsia and 2011 age matched women with previous normotensive pregnancy. All women in this study were retrospectively recruited from the Nord-Trøndelag Health Study (HUNT2). Information from HUNT2 was linked to the Medical Birth Registry of Norway to identify women with a history of preeclampsia and women without a history of preeclampsia.
Results
No significant association was found between hypertension (blood pressure ≥140/90 mmHg and/or taking antihypertensive drugs) and the polymorphism in crude analysis (OR (95% CI): CG genotype: 1.07 (0.90-1.27); GG genotype: 1.23 (0.90-1.67)). However, in a minimally adjusted model (age and BMI adjusted), a significant association between the GG genotype and hypertension was found (OR (95% CI): 1.49 (1.05-2.11)). This association remained significant also after adjustment for a history of preeclampsia (OR (95% CI): 1.46 (1.02-2.09)), but not in a model adjusted for multiple other variables (OR (95% CI): 1.26 (0.82-1.94)). In multivariate, but not in crude, analysis, the GG genotype of rs4606 (OR (95% CI): 1.93 (1.05-3.53)) was significantly and independently associated with severe hypertension later in life, defined as systolic blood pressure ≥160 mmHg (stage 2 hypertension) and/or taking antihypertensive drugs. A significant association was also found for the merged CG and GG genotypes (OR (95% CI): 1.43 (1.02-2.00)). Moreover, an interaction with physical activity was found. A history of preeclampsia was a significant and independent predictor of either definition of hypertension, both in crude and adjusted analyses.
Conclusion
Women carrying the rs4606 CG or GG genotype are at elevated risk for developing hypertension after delivery. Physical activity may interact with the association. Preeclampsia remains an independent risk factor for subsequent hypertension after adjusting for this polymorphism and classical CVD risk factors. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BMC (part of Springer Nature) | nb_NO |
dc.relation.uri | http://www.biomedcentral.com/content/pdf/1471-2350-15-28.pdf | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: Data from the Norwegian HUNT2 study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 10 | nb_NO |
dc.source.volume | 15 | nb_NO |
dc.source.journal | BMC Medical Genetics | nb_NO |
dc.source.issue | 28 | nb_NO |
dc.identifier.doi | 10.1186/1471-2350-15-28 | |
dc.identifier.cristin | 1168247 | |
dc.description.localcode | © 2014 Kvehaugen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |