dc.contributor.author | Pettersen, Klas | |
dc.contributor.author | Bugenhagen, Scott M. | |
dc.contributor.author | Nauman, Javaid | |
dc.contributor.author | Beard, Daniel A. | |
dc.contributor.author | Omholt, Stig W | |
dc.date.accessioned | 2019-11-07T10:50:40Z | |
dc.date.available | 2019-11-07T10:50:40Z | |
dc.date.created | 2014-09-03T17:20:42Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.uri | http://hdl.handle.net/11250/2627152 | |
dc.description.abstract | Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Public Library of Science | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | PLoS Computational Biology | nb_NO |
dc.source.issue | 5 | nb_NO |
dc.identifier.doi | 10.1371/journal.pcbi.1003634 | |
dc.identifier.cristin | 1151567 | |
dc.description.localcode | 2014 Pettersen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | nb_NO |
cristin.unitcode | 194,65,25,0 | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |