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dc.contributor.authorOhara, Shinya
dc.contributor.authorGianatti, Michele
dc.contributor.authorItou, Kazuki
dc.contributor.authorBerndtsson, Christin Høiberget
dc.contributor.authorDoan, Thanh Pierre
dc.contributor.authorKitanishi, Takuma
dc.contributor.authorMizuseki, Kenju
dc.contributor.authorIjima, Toshio
dc.contributor.authorTsutsui, Ken-Ishiro
dc.contributor.authorWitter, Menno
dc.description.abstractIn the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of the lateral and medial subdivisions of the entorhinal cortex. Using elaborate quantitative retrograde tracing, complemented by anterograde tracing, we report that the layer II CB+ population comprises neurons with diverse, mainly excitatory projections. At least half of them originate local intrinsic and commissural projections which distribute mainly to layer I and II. We further show that long-range CB+ projections from the two entorhinal subdivisions differ substantially in that MEC projections mainly target field CA1 of the hippocampus, whereas LEC CB+ projections distribute much more widely to a substantial number of known forebrain targets. This connectional difference between the CB+ populations in LEC and MEC is reminiscent of the overall projection pattern of the two entorhinal subdivisions.nb_NO
dc.publisherFrontiers Medianb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleEntorhinal layer II calbindin-expressing neurons originate widespread telencephalic and intrinsic projectionsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalFrontiers in Systems Neurosciencenb_NO
dc.description.localcodeCopyright © 2019 Ohara, Gianatti, Itou, Berndtsson, Doan, Kitanishi, Mizuseki, Iijima, Tsutsui and Witter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)nb_NO
cristin.unitnameKavliinstitutt for nevrovitenskap

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Navngivelse 4.0 Internasjonal
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