dc.contributor.author | Ligaarden, Solveig Catharina | |
dc.contributor.author | Lydersen, Stian | |
dc.contributor.author | Farup, Per Grønaas | |
dc.date.accessioned | 2019-10-14T11:20:15Z | |
dc.date.available | 2019-10-14T11:20:15Z | |
dc.date.created | 2013-02-19T09:30:36Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | BMC Gastroenterology. 2012, 12 . | nb_NO |
dc.identifier.issn | 1471-230X | |
dc.identifier.uri | http://hdl.handle.net/11250/2621961 | |
dc.description.abstract | Background
Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensitivity remains inconclusive. The primary aim of this study was to compare food- and yeast-specific IgG and IgG4 antibodies in subjects with and without IBS.
Methods
This was a case control study in the general population for which subjects completed questionnaires about abdominal complaints and their intake of common food items. Blood samples were collected, and food- and yeast-specific IgG and IgG4 antibodies were measured. Antibodies were measured in mg/L.
Results
We included 269 subjects with IBS and 277 control subjects. After correction for subject characteristics and diet, there were no significant differences with regard to food- and yeast-specific IgG and IgG4 antibodies between subjects with IBS and controls. Lower values of IgG antibodies against egg (OR 0.99 (0.98 to 1.00), p = 0.002) and beef (OR 0.75 (0.60 to 0.94), p = 0.012) and higher values of IgG antibodies against chicken (OR 1.14 (1.03 to 1.27), p = 0.009) were associated with more severe symptoms.
Conclusions
Our findings suggest that IgG-and IgG4-mediated food and yeast hypersensitivity in IBS is unlikely. IgG antibodies against food and yeast may reflect the diet. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BMC (part of Springer Nature) | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | IgG and IgG4 antibodies in subjects with irritable bowel syndrome: a case control study in the general population | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 8 | nb_NO |
dc.source.volume | 12 | nb_NO |
dc.source.journal | BMC Gastroenterology | nb_NO |
dc.identifier.doi | 10.1186/1471-230X-12-166 | |
dc.identifier.cristin | 1012024 | |
dc.description.localcode | © 2012 Ligaarden et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,65,35,5 | |
cristin.unitname | Institutt for klinisk og molekylær medisin | |
cristin.unitname | RKBU Midt-Norge - Regionalt kunnskapssenter for barn og unge - psykisk helse og barnevern | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |