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dc.contributor.authorNordgård, Catherine Taylor
dc.contributor.authorDraget, Kurt Ingar
dc.date.accessioned2019-10-01T08:58:36Z
dc.date.available2019-10-01T08:58:36Z
dc.date.created2018-12-10T20:43:54Z
dc.date.issued2018
dc.identifier.citationAdvanced Drug Delivery Reviews. 2018, 124 175-183.nb_NO
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/11250/2619544
dc.description.abstractNanoparticulate drug delivery systems (nDDS) offer a variety of options when it comes to routes of administration. One possible path is crossing mucosal barriers, such as in the airways and in the GI tract, for systemic distribution or local treatment. The main challenge with this administration route is that the size and surface properties of the nanoparticles, as opposed to small molecular drugs, very often results in mucosal capture, immobilization and removal, which in turn results in a very low bioavailability. Strategies to overcome this challenge do exist, like surface ‘stealth’ modification with PEG. Here we review an alternative or supplemental strategy, co-association of mucus modulating agents with the nDDS to improve bioavailability, where the nDDS may be surface modified or unmodified. This contribution presents some examples on how possible co-association systems may be achieved, using currently marketed mucolytic drugs, alternative formulations or novel agents.nb_NO
dc.language.isoengnb_NO
dc.publisherElseviernb_NO
dc.titleCo association of mucus modulating agents and nanoparticles for mucosal drug deliverynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber175-183nb_NO
dc.source.volume124nb_NO
dc.source.journalAdvanced Drug Delivery Reviewsnb_NO
dc.identifier.doi10.1016/j.addr.2018.01.001
dc.identifier.cristin1641386
dc.description.localcode© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/nb_NO
cristin.unitcode194,66,15,0
cristin.unitnameInstitutt for bioteknologi og matvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode1


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