dc.contributor.author | Rongve, Arvid | |
dc.contributor.author | Witoelar, Aree | |
dc.contributor.author | Ruiz, Agustín | |
dc.contributor.author | Athanasiu, Lavinia | |
dc.contributor.author | Abdelnour, Carla | |
dc.contributor.author | Clarimon, Jordi | |
dc.contributor.author | Heilmann-Heimbach, Stefanie | |
dc.contributor.author | Hernández, Isabel | |
dc.contributor.author | Moreno-Grau, Sonia | |
dc.contributor.author | de Rojas, Itziar | |
dc.contributor.author | Morenas-Rodríguez, Estrella | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Sando, Sigrid Botne | |
dc.contributor.author | Bråthen, Geir | |
dc.contributor.author | Blanc, Frédéric | |
dc.contributor.author | Bousiges, Olivier | |
dc.contributor.author | Lemstra, Afina W. | |
dc.contributor.author | van Steenoven, Inger | |
dc.contributor.author | Londos, Elisabet | |
dc.contributor.author | Almdahl, Ina Selseth | |
dc.contributor.author | Pålhaugen, Lene | |
dc.contributor.author | Eriksen, Jon Alm | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Stordal, Eystein | |
dc.contributor.author | Saltvedt, Ingvild | |
dc.contributor.author | Ulstein, Ingun | |
dc.contributor.author | Bettella, Francesco | |
dc.contributor.author | Desikan, Rahul S. | |
dc.contributor.author | Idland, Ane-Victoria | |
dc.contributor.author | Toft, Mathias | |
dc.contributor.author | Pihlstrøm, Lasse | |
dc.contributor.author | Snaedal, Jon | |
dc.contributor.author | Tárraga, Lluís | |
dc.contributor.author | Boada, Mercè | |
dc.contributor.author | Lleó, Alberto | |
dc.contributor.author | Stefánsson, Hreinn | |
dc.contributor.author | Stefánsson, Kári | |
dc.contributor.author | Ramírez, Alfredo | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.date.accessioned | 2019-09-24T11:20:57Z | |
dc.date.available | 2019-09-24T11:20:57Z | |
dc.date.created | 2019-06-28T09:24:32Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Scientific Reports. 2019, 9 (7013) | nb_NO |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/11250/2618473 | |
dc.description.abstract | Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 720 DLB cases and 6490 controls and included 19 top-associated single-nucleotide polymorphisms in an additional cohort of 108 DLB cases and 75545 controls from Iceland. Overall the study included 828 DLB cases and 82035 controls. Variants in the ASH1L/GBA (Chr1q22) and APOE ε4 (Chr19) loci were associated with DLB surpassing the genome-wide significance threshold (p < 5 × 10−8). One additional genetic locus previously linked to psychosis in Alzheimer’s disease, ZFPM1 (Chr16q24.2), showed suggestive association with DLB at p-value < 1 × 10−6. We report two susceptibility loci for DLB at genome-wide significance, providing insight into etiological factors. These findings highlight the complex relationship between the genetic architecture of DLB and other neurodegenerative disorders. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.volume | 9 | nb_NO |
dc.source.journal | Scientific Reports | nb_NO |
dc.source.issue | 7013 | nb_NO |
dc.identifier.doi | 10.1038/s41598-019-43458-2 | |
dc.identifier.cristin | 1708523 | |
dc.description.localcode | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. | nb_NO |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 1920,16,0,0 | |
cristin.unitcode | 194,65,35,0 | |
cristin.unitcode | 1920,15,0,0 | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | Nevroklinikken | |
cristin.unitname | Institutt for psykisk helse | |
cristin.unitname | Medisinsk klinikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |