dc.contributor.author | Jalili, Mahsa | |
dc.contributor.author | Vahedi, Homayoon | |
dc.contributor.author | Poustchi, Hossein | |
dc.contributor.author | Hekmatdoost, Azita | |
dc.date.accessioned | 2019-09-24T06:28:42Z | |
dc.date.available | 2019-09-24T06:28:42Z | |
dc.date.created | 2019-02-19T11:21:10Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | International Journal of Preventive Medicine. 2019, 10 (1), 16-?. | nb_NO |
dc.identifier.issn | 2008-7802 | |
dc.identifier.uri | http://hdl.handle.net/11250/2618331 | |
dc.description.abstract | There are some evidence that Vitamin D supplementation may be beneficial for patients with irritable bowel syndrome (IBS). The aim of this study was to evaluate the effects of Vitamin D supplementation on symptoms and quality of life (QOL) in patients with IBS. Methods: In a randomized, double blind, placebo controlled clinical trial, 116 patients with IBS were supplemented weekly with either a pearl of 50,000 IU Vitamin D or an identical pearl of placebo containing medium chain triglyceride for 6 weeks. Results: Mean age of patients was 42.24 ± 12.26, and 40.06 ± 13.37 in Vitamin D and placebo groups, respectively. Dietary intakes were similar between and within groups. Serum concentration of 25 hydroxy Vitamin D increased significantly from 21.10 ± 5.23 to 36.43 ± 12.34 in the Vitamin D group (P < 0.001), while it was not significantly different before and after the trial in placebo group. The IBS symptoms severity scores (SSSs), disease specific QOL, and total score were evaluated at weeks 0 and 6. IBS SSS, IBS QOL, and the total score were improved significantly more in Vitamin D group in comparison to the placebo group (P < 0.05). Conclusions: This study indicates that Vitamin D therapy can improve the severity of symptoms and QOL in patients with IBS; however, the long term effects remained to be elucidated.
Trial registration at IRCT: IRCT201402234010N11
IRB Number: 116/3976 | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wolters Kluwer Health | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.no | * |
dc.title | Effects of Vitamin D supplementation in patients with irritable bowel syndrome: A randomized, double-blind, placebo-controlled clinical trial | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 16-? | nb_NO |
dc.source.volume | 10 | nb_NO |
dc.source.journal | International Journal of Preventive Medicine | nb_NO |
dc.source.issue | 1 | nb_NO |
dc.identifier.cristin | 1678666 | |
dc.description.localcode | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. | nb_NO |
cristin.unitcode | 194,66,10,0 | |
cristin.unitname | Institutt for biologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |