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dc.contributor.authorLiang, Robin Amanda
dc.contributor.authorHøiland, Ina Isabella
dc.contributor.authorUeland, Thor
dc.contributor.authorAukrust, Pål
dc.contributor.authorSnir, Omri
dc.contributor.authorHindberg, Kristian
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorGarred, Peter
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2019-09-16T11:10:27Z
dc.date.available2019-09-16T11:10:27Z
dc.date.created2019-09-09T14:19:39Z
dc.date.issued2019
dc.identifier.citationJournal of Thrombosis and Haemostasis. 2019, 1-9.nb_NO
dc.identifier.issn1538-7933
dc.identifier.urihttp://hdl.handle.net/11250/2616971
dc.description.abstractBackground Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose‐binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease. Objectives To investigate the association between plasma MBL levels and future risk of incident VTE. Methods We conducted a nested case‐control study in 417 VTE patients and 849 age‐matched and sex‐matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme‐linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels. Results Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56‐1.10) and for DVT (OR 0.70, 95% CI: 0.47‐1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event. Conclusions Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titlePlasma levels of mannose-binding lectin and future risk of venous thromboembolismnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1-9nb_NO
dc.source.journalJournal of Thrombosis and Haemostasisnb_NO
dc.identifier.doi10.1111/jth.14539
dc.identifier.cristin1722878
dc.description.localcodeThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. © 2019 The Authorsnb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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