Synthesis of Pyrrolopyrimidines for Investigation of JAK2 Inhibition
Master thesis
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http://hdl.handle.net/11250/2615664Utgivelsesdato
2015Metadata
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- Institutt for kjemi [1353]
Sammendrag
A series of 7H-pyrrolo- and thieno[2,3-d]pyrimidine based compounds have been synthesized and tested for Janus kinase 2 (JAK2) inhibition, as part of a fragment-based approach to obtaining information on structure-activity relationships.At the same time, improvements have been achieved regarding pyrrole protectinggroups and amination of fused pyrimidines.