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dc.contributor.authorMuller, David C.
dc.contributor.authorLarose, Tricia L
dc.contributor.authorHodge, Allison
dc.contributor.authorGuida, Florence
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorMeyer, Klaus
dc.contributor.authorCai, Qiuyin
dc.contributor.authorArslan, Alan A.
dc.contributor.authorZeleniuch-Jacquotte, Anne
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorGiles, Graham G.
dc.contributor.authorSesso, Howard D.
dc.contributor.authorLee, I-Min
dc.contributor.authorGaziano, J. Michael
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorHoffman Bolton, Judith
dc.contributor.authorBuring, Julie E.
dc.contributor.authorVisvanathan, Kala
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorPurdue, Mark P.
dc.contributor.authorCaporaso, Neil E.
dc.contributor.authorMidttun, Øivind
dc.contributor.authorUeland, Per Magne
dc.contributor.authorPrentice, Ross L.
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorZheng, Wei
dc.contributor.authorBlot, William J.
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorZhang, Xuehong
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorHveem, Kristian
dc.contributor.authorThomson, Cynthia A.
dc.contributor.authorPettinger, Mary
dc.contributor.authorEngström, Gunnar
dc.contributor.authorBrunnström, Hans
dc.contributor.authorMilne, Roger L.
dc.contributor.authorStampfer, Meir J.
dc.contributor.authorHan, Jiali
dc.contributor.authorJohansson, Mikael
dc.contributor.authorBrennan, Paul
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorJohansson, Mattias
dc.identifier.citationBMJ-BRITISH MEDICAL JOURNAL. 2019, 364:k4981 1-9.nb_NO
dc.description.abstractObjectives: Inflammation may play an important role in lung cancer pathogenesis. Previous studies have suggested an association between C-reactive protein (CRP) as a marker of inflammation, and risk of lung cancer, but have lacked power to comprehensively investigate associations by smoking status and histological subtype. Our objective was to conduct a comprehensive analysis of prospectively measured circulating high-sensitivity CRP (hs-CRP) concentration and risk of lung cancer overall, by smoking status (current, former and never smokers), and histological sub-type. Design: Pooled analysis of prospective case-control studies nested within 20 population cohort studies. Setting: Population-based cohort studies in the Asia, Europe, Australia, and the United States. Participants: 5299 incident lung cancer cases, with individually incidence-density matched controls. Exposure: Circulating hs-CRP concentrations in pre-diagnostic serum/plasma samples. Main Outcome Measure: Incident lung cancer diagnosis. Results: We observed a positive association between circulating hs-CRP concentration and risk of lung cancer for current (OR per doubling in hs-CRP [ORlog2CRP]: 1.09, 95% CI: 1.05 to 1.13) and former smokers (ORlog2CRP 1.09, 95% CI: 1.04 to 1.14), but not never smokers (p-interaction <0.01). This association was strong and consistent across all histological subtypes, with the exception of adenocarcinoma, which was not strongly associated with risk regardless of smoking status (ORlog2CRP adenocarcinoma overall: 0.97, 95%CI: 0.94 to 1.01). Among current and former smokers, the associations were strongest within the first two years of follow-up. Including hs-CRP in a risk model in addition to smoking-based variables did not improve risk discrimination overall, but slightly improved discrimination for cancers diagnosed in the first two years of follow-up. Conclusions: Ever smokers with higher circulating hs-CRP concentrations had higher risk of lung cancer overall. hs-CRP was not associated with risk of lung adenocarcinoma. Circulating hs-CRP concentration may be a pre-diagnostic marker of lung cancer rather than a causal risk factor.nb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCirculating high sensitivity C reactive protein concentrations and risk of lung cancer: Nested case-control study within Lung Cancer Cohort Consortiumnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.relation.projectNorges forskningsråd: 267776/H10nb_NO
dc.description.localcodeThis is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag

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