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dc.contributor.authorStrand, Linn B
dc.contributor.authorTsai, Min Kuang
dc.contributor.authorWen, Chi Pang
dc.contributor.authorChang, Shu-Sen
dc.contributor.authorBrumpton, Ben Michael
dc.identifier.citationBMJ Open. 2018, 8:e019992 (5), 1-8.nb_NO
dc.description.abstractObjectives A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD. Design Prospective cohort study. Setting A large health check-up programme from 1994 to 2011 in Taipei, Taiwan. Participants 446 346 Taiwanese adults. Each participant answered questions regarding asthma history (yes/no) and current daily use of asthma medications (yes/no). Active asthma was defined as those using current daily medications for asthma. Outcomes The participants were followed for mortality from CVD, coronary heart disease (CHD) and stroke obtained through linkage to the cause-of-death register until 31 December 2011. Results We found an increased risk of dying from CVD in individuals with active asthma (adjusted HR (aHR) 1.32, 95% CI 1.08 to 1.62). The risk of death from CHD or stroke was increased in a similar manner (aHR 1.16, 95% CI 0.78 to 1.73 and aHR 1.23, 95% CI 0.86 to 1.74, respectively) although the HR estimates were less precise than that of CVD. For deaths from CVD, CHD and stroke, we found stronger associations with active asthma than non-active asthma, and for CVD and stroke stronger associations in men than women. Conclusion Our study suggests that asthma, particularly active asthma, may be associated with adverse cardiovascular consequences.nb_NO
dc.publisherBMJ Publishing Groupnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleIs having asthma associated with an increased risk of dying from cardiovascular disease? A prospective cohort study of 446 346 Taiwanese adultsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBMJ Opennb_NO
dc.description.localcodeThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:// crea tivecommons. org/ licenses/ by- nc/ 4. 0/ © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameKlinikk for lunge og arbeidsmedisin

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal