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dc.contributor.authorOrrem, Hilde Lang
dc.contributor.authorShetelig, Christian
dc.contributor.authorUeland, Thor
dc.contributor.authorLimalanathan, Shanmuganathan
dc.contributor.authorNilsson, Per
dc.contributor.authorHusebye, Trygve Guttorm
dc.contributor.authorAukrust, Pål
dc.contributor.authorSeljeflot, Ingebjørg
dc.contributor.authorHOFFMANN, PAVEL
dc.contributor.authorEritsland, Jan
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorAndersen, Geir Øystein
dc.contributor.authorYndestad, Arne
dc.identifier.citationInternational Journal of Cardiology. 2018, 268 187-192.nb_NO
dc.description.abstractBackground The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling. Methods Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n = 65). Results IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates. Conclusion Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.titleSoluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarctionnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalInternational Journal of Cardiologynb_NO
dc.description.localcode© 2018. This is the authors’ accepted and refereed manuscript to the article. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
cristin.unitnameFakultet for medisin og helsevitenskap

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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