dc.contributor.author | Orrem, Hilde Lang | |
dc.contributor.author | Shetelig, Christian | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Limalanathan, Shanmuganathan | |
dc.contributor.author | Nilsson, Per | |
dc.contributor.author | Husebye, Trygve Guttorm | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Seljeflot, Ingebjørg | |
dc.contributor.author | HOFFMANN, PAVEL | |
dc.contributor.author | Eritsland, Jan | |
dc.contributor.author | Mollnes, Tom Eirik | |
dc.contributor.author | Andersen, Geir Øystein | |
dc.contributor.author | Yndestad, Arne | |
dc.date.accessioned | 2019-07-08T12:06:57Z | |
dc.date.available | 2019-07-08T12:06:57Z | |
dc.date.created | 2018-06-21T13:38:01Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | International Journal of Cardiology. 2018, 268 187-192. | nb_NO |
dc.identifier.issn | 0167-5273 | |
dc.identifier.uri | http://hdl.handle.net/11250/2603747 | |
dc.description.abstract | Background
The inflammatory response following myocardial infarction (MI) is prerequisite for proper healing of infarcted tissue, but can also have detrimental effects on cardiac function. Interleukin (IL)-1α and IL-1β are potent inflammatory mediators and their bioactivity is tightly regulated by IL-1 receptor antagonist (IL-1ra) and soluble (s) IL-1 receptors (R). We aimed to examine whether levels of soluble regulators of IL-1 signalling are changed during ST-elevation MI (STEMI) and their associations with parameters of cardiac injury and ventricular remodelling.
Methods
Plasma levels of IL-1Ra, sIL-1R1, sIL-1R2 and sIL-1R accessory protein (sIL-1RAcP) were measured by immunoassays in repeated samples from patients with STEMI (n = 255) and compared to healthy controls (n = 65).
Results
IL-1Ra, sIL-1R1 and sIL-1R2 levels were all significantly elevated after STEMI, while levels of sIL-1RAcP were lower compared to controls. sIL-1R2 levels (at different time points) correlated positively with C-reactive protein, myocardial infarct size and change in indexed left ventricular end-diastolic and end-systolic volume (LVEDVi and LVESVi) measured by cardiac MR acutely and after 4 months, and negatively with LV ejection fraction. Patients with >median levels of sIL-1R2 in the acute phase were more likely to have increased change in LVEDVi and LVESVi. Importantly, sIL-1R2 remained significantly associated with change in LVEDVi and LVESVi also after adjustment for clinical covariates.
Conclusion
Levels of sIL-1R2 are independently associated with parameters of LV adverse remodelling following STEMI. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 187-192 | nb_NO |
dc.source.volume | 268 | nb_NO |
dc.source.journal | International Journal of Cardiology | nb_NO |
dc.identifier.doi | 10.1016/j.ijcard.2018.05.032 | |
dc.identifier.cristin | 1592948 | |
dc.description.localcode | © 2018. This is the authors’ accepted and refereed manuscript to the article. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | nb_NO |
cristin.unitcode | 194,65,0,0 | |
cristin.unitname | Fakultet for medisin og helsevitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |