Blar i St. Olavs hospital på forfatter "Åsvold, Bjørn Olav"

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    • Smoking, use of smokeless tobacco, HLA genotypes and incidence of latent autoimmune diabetes in adults 

      Edstorp, Jessica; Wei, Yuxia; Ahlqvist, Emma; Alfredsson, Lars; Grill, Valdemar Erik Robert; Groop, Leif; Rasouli, Bahareh; Sørgjerd, Elin Pettersen; Thorsby, Per Medbøe; Tuomi, Tiinamaija; Åsvold, Bjørn Olav; Carlsson, Sofia (Peer reviewed; Journal article, 2022)
      Aims/hypotheses Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults ...

    • Subclinical thyroid dysfunction and depressive symptoms: protocol for a systematic review and individual participant data meta-analysis of prospective cohort studies 

      Wildisen, Lea; Moutzouri, Elisavet; Beglinger, Shanthi; Syrogiannouli, Lamprini; Cappola, Anne R.; Åsvold, Bjørn Olav; Bakker, Stephan JL; Ceresini, Graziano; Dullaart, Robin P.F.; Ferrucci, Luigi; Grabe, Hans; Jukema, J Wouter; Nauck, Matthias; Trompet, Stella; Völzke, Henry; Westendorp, Rudi G.J.; Gussekloo, Jacobijn; Peeters, Robin P.; Kloppel, Stefan; Aujesky, Drahomir; Bauer, Douglas C.; Rodondi, Nicolas; Del Giovane, Cinzia; Feller, Martin (Journal article; Peer reviewed, 2019)
      IntroductionProspective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms have yielded conflicting findings, possibly because of differences in age, sex, thyroid-stimulating ...

    • Taller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization study 

      Howe, Laurence J.; Brumpton, Ben Michael; Rasheed, Humaira; Åsvold, Bjørn Olav; Davey Smith, George; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Background: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships ...

    • Ten-Year Cardiovascular Disease Risk Trajectories by Obstetric History: A Longitudinal Study in the Norwegian HUNT Study 

      Fraser, Abigail; Markovitz, Amanda R.; Haug, Eirin Beate; Horn, Julie; Romundstad, Pål Richard; Dalen, Håvard; Rich-Edwards, Janet Wilson; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2022)
      Background Women with a history of obstetric complications are at increased risk of cardiovascular disease, but whether they should be specifically targeted for cardiovascular disease (CVD) risk screening is unknown. Methods ...

    • Thyroid function, pernicious anemia and erythropoiesis: a two-sample Mendelian randomization study 

      Kjaergaard, Alisa D.; Teumer, Alexander; Marouli, Eirini; Deloukas, Panos; Kuś, Aleksander; Sterenborg, Rosalie; Åsvold, Bjørn Olav; Medici, Marco; Ellervik, Christina (Peer reviewed; Journal article, 2022)
      Autoimmune thyroid disease (AITD) and pernicious anemia (PA) often coexist, but the directionality is unknown. In a two-sample Mendelian randomization (MR) analysis, using summary statistics from large genome-wide association ...

    • Thyroid hypofunction in aging testicular cancer survivors 

      Nome, Ragnhild V.; Småstuen, Milada Cvancarova; Fosså, Sophie D.; Kiserud, Cecilie E.; Åsvold, Bjørn Olav; Bjøro, Trine (Peer reviewed; Journal article, 2021)
      Purpose Thyroid hypofunction is a late effect observed in several groups of cancer survivors, but has to date not been evaluated in-depth in testicular cancer survivors (TCSs). We investigated the prevalence of thyroid ...

    • Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin 

      Trouva, Anastasia; Alvarsson, Michael; Calissendorff, Jan; Åsvold, Bjørn Olav; Vanky, Eszter; Hirschberg, Angelica Lindén (Peer reviewed; Journal article, 2022)
      Objective: Polycystic ovary syndrome (PCOS) and hypothyroidism are related conditions, and both are associated with adverse pregnancy outcomes. Knowledge is lacking about the complex interaction between thyroid status and ...

    • Trace elements in whole blood in the general population in Trøndelag County, Norway: The HUNT3 Survey 

      Simic, Anica; Hansen, Ailin Falkmo; Syversen, Tore; Lierhagen, Syverin; Ciesielski, Tomasz Maciej; Romundstad, Pål Richard; Midthjell, Kristian; Åsvold, Bjørn Olav; Flaten, Trond Peder (Journal article; Peer reviewed, 2021)
      Background: Biomonitoring of a cohort within a large health survey can provide reliable information on trace element status. The main aims of this study were 1) to determine the concentrations of 28 trace elements in whole ...

    • Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease 

      Zheng, Jie; Zhang, Yuemiao; Rasheed, Humaira; Walker, Venexia M.; Sugawara, Yuka; Li, Jiachen; Leng, Yue; Elsworth, Benjamin; Wootton, Robyn E.; Fang, Si; Yang, Qian; Burgess, Stephen; Haycock, Philip C.; Borges, Maria Carolina; Carnegie, Rebecca; Cho, Yoonsu; Howell, Amy; Robinson, Jamie; Thomas, Laurent; Brumpton, Ben Michael; Hveem, Kristian; Hallan, Stein; Franceschini, Nora; Morris, Andrew P.; Köttgen, Anna; Pattaro, Cristian; Wuttke, Matthias; Yamamoto, Masayuki; Kashihara, Naoki; Akiyama, Masato; Kanai, Masahiro; Matsuda, Koichi; Kamatani, Yoichiro; Okada, Yukinori; Walters, Robin; Millwood, Iona Y.; Chen, Zhengming; Smith, George Davey; Barbour, Sean; Yu, Canqing; Åsvold, Bjørn Olav; Zhang, Hong; Gaunt, Tom R. (Peer reviewed; Journal article, 2021)
      Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. ...

    • Undiagnosed diabetes: Prevalence and cardiovascular risk profile in a population-based study of 52,856 individuals. The HUNT Study, Norway 

      Bjarkø, Vera Vik; Haug, Eirin Beate; Sørgjerd, Elin Pettersen; Stene, Lars Christian Mørch; Lopez-Doriga Ruiz, Paz; Birkeland, Kåre Inge; Berg, Tore Julsrud; Gulseth, Hanne Løvdal; Iversen, Marjolein M.; Langhammer, Arnulf; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2022)
      Aims We investigated the current extent of undiagnosed diabetes and prediabetes and their associated cardiovascular risk profile in a population-based study. Methods All residents aged ≥20 years in the Nord-Trøndelag ...

    • Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study 

      Moen, Gunn-Helen Øiseth; Nivard, Michel; Bhatta, Laxmi; Warrington, Nicole Maree; Willer, Cristen; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M. (Peer reviewed; Journal article, 2022)
      The Barker Hypothesis posits that adverse intrauterine environments result in fetal growth restriction and increased risk of cardiometabolic disease through developmental compensations. Here we introduce a new statistical ...

    • Variation in serum PCSK9 (proprotein convertase subtilisin/kexin type 9), cardiovascular disease risk, and an investigation of potential unanticipated effects of PCSK9 inhibition 

      Brumpton, Ben Michael; Fritsche, Lars; Zheng, Jie; Nielsen, Jonas Bille; Mannila, Maria Nastase; Surakka, Ida; Rasheed, Humaira; Vie, Gunnhild Åberge; Graham, Sarah E.; Gabrielsen, Maiken Elvestad; Laugsand, Lars Erik; Aukrust, Pål; Vatten, Lars Johan; Damås, Jan Kristian; Ueland, Thor; Janszky, Imre; Zwart, John-Anker; van't Hooft, Ferdinand M.; Seidah, Nabil Georges; Hveem, Kristian; Willer, Cristen; Smith, George Davey; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2019)
      PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce serum LDL (low-density lipoprotein) cholesterol (LDL-C) by increasing uptake in the liver. Although some long-term trials have evaluated their safety, ...

    • Vitamin D Status among Women in a Rural District of Nepal: Determinants and Association with Metabolic Profile—A Population-Based Study 

      Yogal, Chandra; Borgen, Marianne; Shakya, Sunila; Karmarcharya, Biraj; Koju, Rajendra; Mosti, Mats Peder; Gustafsson, Miriam K.; Åsvold, Bjørn Olav; Schei, Berit; Stunes, Astrid Kamilla; Syversen, Unni (Peer reviewed; Journal article, 2022)
      Hypovitaminosis D is prevalent worldwide, and especially in South-Asia. According to the Institute of Medicine (IOM), 25(OH)D levels below 30 nmol/L are defined as vitamin D deficiency (VDD) and levels between 30–50 nmol/L ...

    • Vitamin D status and risk of type 2 diabetes in the Norwegian HUNT cohort study: Does family history or genetic predisposition modify the association? 

      Denos, Marion; Mai, Xiao-Mei; Åsvold, Bjørn Olav; Sørgjerd, Elin Pettersen; Chen, Yue; Sun, Yi-Qian (Peer reviewed; Journal article, 2021)
      Introduction We sought to investigate the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and the risk of type 2 diabetes mellitus (T2DM) in adults who participated in the Trøndelag Health Study (HUNT), and ...

    • Which combined nerve conduction study scores are best suited for polyneuropathy in diabetic patients? 

      Dunker, Øystein; Nilsen, Kristian Bernhard; Olsen, Sandra Elise; Åsvold, Bjørn Olav; Bjørgaas, Marit Ragnhild Rokne; Sand, Trond (Peer reviewed; Journal article, 2021)
      Introduction/Aims Nerve conduction studies (NCS) are widely used in diagnosing diabetic polyneuropathy. Combining the Z scores of several measures (Z-compounds) may improve diagnostics by grading abnormality. We aimed to ...

    • Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 

      Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Peer reviewed; Journal article, 2022)
      Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...

    • X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements 

      Scholz, Markus; Horn, Katrin; pott, janne; Wuttke, Matthias; Hallan, Stein Ivar; Schlosser, Pascal; Pattaro, Cristian; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Hveem, Kristian; Thomas, Laurent Francois; Rasheed, Humaira (Peer reviewed; Journal article, 2024)
      X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis ...