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dc.contributor.authorKirsebom, Bjørn-Eivind Seljelid Bordewic
dc.contributor.authorEspenes, Ragna
dc.contributor.authorWaterloo, Knut
dc.contributor.authorHessen, Erik
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorBråthen, Geir
dc.contributor.authorAarsland, Dag
dc.contributor.authorFladby, Tormod
dc.date.accessioned2019-04-26T07:42:32Z
dc.date.available2019-04-26T07:42:32Z
dc.date.created2017-10-08T13:17:26Z
dc.date.issued2017
dc.identifier.citationJournal of Alzheimer's Disease. 2017, 60 (4), 1621-1631.nb_NO
dc.identifier.issn1387-2877
dc.identifier.urihttp://hdl.handle.net/11250/2595602
dc.description.abstractBackground: Cognitive assessment is essential in tracking disease progression in AD. Presently, cohorts including preclinical at-risk participants are recruited by different means, which may bias cognitive and clinical features. We compared recruitment strategies to levels of cognitive functioning. Objective: We investigate recruitment source biases in self-referred and memory clinic-referred patient cohorts to reveal potential differences in cognitive performance and demographics among at-risk participants. Methods: We included 431 participants 40–80 years old. Participants were classified as controls (n = 132) or symptom group (n = 299). The symptom group comprised of subjective cognitive decline (SCD, n = 163) and mild cognitive impairment (MCI, n = 136). We compared cognitive performance and demographics in memory clinic-referrals (n = 86) to self-referred participants responding to advertisements and news bulletins (n = 179). Participants recruited by other means were excluded from analysis (n = 34). Results: At symptom group level, we found significant reductions in cognitive performance in memory clinic-referrals compared to self-referrals. However, here reductions were only found within the MCI group. We found no differences in cognitive performance due to recruitment within the SCD group. The MCI group was significantly impaired compared to controls on all measures. Significant reductions in learning, and executive functions were also found for the SCD group. Conclusion: Regardless of recruitment method, both the SCD and MCI groups showed reductions in cognitive performance compared to controls. We found differences in cognitive impairment for memory clinic-referrals compared to self-referrals only within the MCI group, SCD-cases being equally affected irrespective of referral type.nb_NO
dc.language.isoengnb_NO
dc.publisherIOS Pressnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleScreening for Alzheimer’s Disease: Cognitive Impairment in Self-Referred and Memory Clinic-Referred Patientsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber1621-1631nb_NO
dc.source.volume60nb_NO
dc.source.journalJournal of Alzheimer's Diseasenb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.3233/JAD-170385
dc.identifier.cristin1503120
dc.relation.projectNorges forskningsråd: 269774nb_NO
dc.description.localcode© 2017 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).nb_NO
cristin.unitcode194,65,30,0
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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