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dc.contributor.authorRønning, Torunn Gresdal
dc.contributor.authorÅs, Christina Gabrielsen
dc.contributor.authorStøen, Ragnhild
dc.contributor.authorBergh, Kåre
dc.contributor.authorAfset, Jan Egil
dc.contributor.authorHolte, Mari Sagli
dc.contributor.authorRadtke, Andreas
dc.date.accessioned2019-04-25T07:43:45Z
dc.date.available2019-04-25T07:43:45Z
dc.date.created2018-09-24T10:37:19Z
dc.date.issued2018
dc.identifier.citationActa Paediatrica. 2018, 1-7.nb_NO
dc.identifier.issn0803-5253
dc.identifier.urihttp://hdl.handle.net/11250/2595374
dc.description.abstractAbstract Aim Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway between April 2016 and April 2017. This study describes the outbreak, infection control measures undertaken and the molecular methods developed. Methods The outbreak prompted detailed epidemiological and microbial investigations, where whole genome sequencing (WGS) was particularly useful for both genotyping and development of two new K. oxytoca specific real‐time PCR assays. Routine screening of patients, as well as sampling from numerous environmental sites, was performed during the outbreak. A bundle of infection control measures was instigated to control the outbreak, among them strict cohort isolation. Results Five neonates had symptomatic infection and 17 were found to be asymptomatically colonized. Infections varied in severity from conjunctivitis to a fatal case of pneumonia. A source of the outbreak could not be determined. Conclusion This report describes K. oxytoca as a significant pathogen in a NICU outbreak setting and highlighs the importance of developing appropriate microbiological screening methods and implementing strict infection control measures to control the outbreak in a setting where the source could not be identified.nb_NO
dc.description.abstractInvestigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norwaynb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titleInvestigation of an outbreak caused by antibiotic susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norwaynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1-7nb_NO
dc.source.journalActa Paediatricanb_NO
dc.identifier.doi10.1111/apa.14584
dc.identifier.cristin1612822
dc.description.localcode© Foundation Acta Paediatrica. Published by John Wiley & Sons LtdThis is the peer reviewed version of the following article: [Investigation of an outbreak caused by antibiotic‐susceptible Klebsiella oxytoca in a neonatal intensive care unit in Norway, Published in Acta Paediatrica, 17 September 2018 ], which has been published in final form at [DOI:10.1111/apa.14584]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.nb_NO
cristin.unitcode194,65,15,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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