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dc.contributor.authorStøylen, Asbjørn
dc.contributor.authorHansen, Harald Edvard Mølmen
dc.contributor.authorDalen, Håvard
dc.date.accessioned2019-03-18T10:24:12Z
dc.date.available2019-03-18T10:24:12Z
dc.date.created2018-02-07T14:03:43Z
dc.date.issued2018
dc.identifier.citationEchocardiography. 2018, 35 (5), 603-610.nb_NO
dc.identifier.issn0742-2822
dc.identifier.urihttp://hdl.handle.net/11250/2590436
dc.description.abstractBackground Left ventricular (LV) systolic long‐axis shortening can be measured as Mitral Annular Plane Systolic Excursion (MAPSE). Global longitudinal strain (GLS) is relative LV shortening, equivalent to normalizing MAPSE for LV length (MAPSEn). The objective of this study was to test whether normalizing LV shortening reduced biological variability of MAPSE due to normalizing for heart size and, possibly BSA. Secondly to provide normal reference values for MAPSE. Methods and results A total of 1266 subjects from the Nord‐Trøndelag Health Study (HUNT), without evidence of heart disease were examined. MAPSE and wall lengths were measured in all three standard apical views, while GLS has been published previously. Mean MAPSE was 1.58 (0.25) cm, MAPSEn 16.3 (2.4)%, and GLS 16.7 (2.4)%. All measures declined with age, correlations between ‐0.50 and −0.41. MAPSE was gender independent, and less BSA dependent than MAPSEn and GLS, while relative standard deviations (SDs) were similar for all three measures. Conclusions MAPSE, MAPSEn, and GLS have similar biological variability, which is mainly due to age variation, indicating they are equivalent in normal, and normalizing for BSA will not reduce the variability. Normalizing MAPSE for LV length (MAPSEn and GLS) normalizes for one dimension only, inducing a systematic error, which increases BSA and gender dependence. Normal age‐related, gender‐independent values for MAPSE are provided.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.relation.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/echo.13825
dc.titleRelation between mitral annular plane systolic excursion and global longitudinal strain in normal subjects: The HUNT studynb_NO
dc.title.alternativeRelation between mitral annular plane systolic excursion and global longitudinal strain in normal subjects: The HUNT studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber603-610nb_NO
dc.source.volume35nb_NO
dc.source.journalEchocardiographynb_NO
dc.source.issue5nb_NO
dc.identifier.doi10.1111/echo.13825
dc.identifier.cristin1562855
dc.description.localcodeThis is the peer reviewed version of an article, which has been published in final form at [https://doi.org/10.1111/echo.13825]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.nb_NO
cristin.unitcode194,65,25,0
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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