dc.contributor.author | Gusarova, Viktoria | |
dc.contributor.author | O'Dushlaine, Colm | |
dc.contributor.author | Teslovich, Tanya M. | |
dc.contributor.author | Benotti, Peter N. | |
dc.contributor.author | Mirshahi, Tooraj | |
dc.contributor.author | Gottesman, Omri | |
dc.contributor.author | van Hout, Cristopher V. | |
dc.contributor.author | Murray, Michael F. | |
dc.contributor.author | Mahajan, Anubha | |
dc.contributor.author | Nielsen, Jonas B. | |
dc.contributor.author | Fritsche, Lars | |
dc.contributor.author | Wulff, Anders Berg | |
dc.contributor.author | Gudbjartsson, Daníel Fannar | |
dc.contributor.author | Sjögren, Marketa | |
dc.contributor.author | Emdin, Connor A. | |
dc.contributor.author | Scott, Robert A. | |
dc.contributor.author | Lee, Wen-Jane | |
dc.contributor.author | Small, Aeron | |
dc.contributor.author | Kwee, Lydia C. | |
dc.contributor.author | Dwivedi, Om Prakash | |
dc.contributor.author | Prasad, Rashmi B. | |
dc.contributor.author | Bruse, Shannon | |
dc.contributor.author | Lopez, Alexander E. | |
dc.contributor.author | Penn, John | |
dc.contributor.author | Marcketta, Anthony | |
dc.contributor.author | Leader, Joseph B. | |
dc.contributor.author | Still, Christopher D. | |
dc.contributor.author | Kirchner, H. Lester | |
dc.contributor.author | Mirshahi, Uyenlinh L. | |
dc.contributor.author | Wardeh, Amr H. | |
dc.contributor.author | Hartle, Cassandra M. | |
dc.contributor.author | Habegger, Lukas | |
dc.contributor.author | Fetterolf, Samantha N. | |
dc.contributor.author | Tusie-Luna, Teresa | |
dc.contributor.author | Morris, Andrew P. | |
dc.contributor.author | Holm, Hilma | |
dc.contributor.author | Steinthorsdóttir, Valgerdur | |
dc.contributor.author | Sulem, Patrick | |
dc.contributor.author | Thorsteinsdóttir, Unnur | |
dc.contributor.author | Rotter, Jerome I. | |
dc.contributor.author | Chuang, Lee-Ming | |
dc.contributor.author | Damrauer, Scott | |
dc.contributor.author | Birtwell, David | |
dc.contributor.author | Brummett, Chad M. | |
dc.contributor.author | Khera, Amit V. | |
dc.contributor.author | Natarajan, Pradeep | |
dc.contributor.author | Orho-Melander, Marju | |
dc.contributor.author | Flannick, Jason | |
dc.contributor.author | Lotta, Luca A. | |
dc.contributor.author | Willer, Cristen J. | |
dc.contributor.author | Holmen, Oddgeir Lingaas | |
dc.contributor.author | Ritchie, Marylyn D. | |
dc.contributor.author | Ledbetter, David H. | |
dc.contributor.author | Murphy, Andrew J. | |
dc.contributor.author | Borecki, Ingrid B. | |
dc.contributor.author | Reid, Jeffrey G. | |
dc.contributor.author | Overton, John D. | |
dc.contributor.author | Hansson, Ola | |
dc.contributor.author | Groop, Leif | |
dc.contributor.author | Shah, Svati H. | |
dc.contributor.author | Kraus, William E. | |
dc.contributor.author | Rader, Daniel J. | |
dc.contributor.author | Chen, Yii-Der Ida | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Wareham, Nicholas J. | |
dc.contributor.author | Kathiresan, Sekar | |
dc.contributor.author | Melander, Olle | |
dc.contributor.author | Stefansson, Kari | |
dc.contributor.author | Nordestgaard, Børge G. | |
dc.contributor.author | Tybjærg-Hansen, Anne | |
dc.contributor.author | Abecasis, Goncalo | |
dc.contributor.author | Altshuler, David | |
dc.contributor.author | Florez, Jose C. | |
dc.contributor.author | Boehnke, Michael | |
dc.contributor.author | McCarthy, Mark I. | |
dc.contributor.author | Yancopoulos, George D. | |
dc.contributor.author | Carey, David J. | |
dc.contributor.author | Shuldiner, Alan R. | |
dc.contributor.author | Baras, Aris | |
dc.contributor.author | Dewey, Frederick E. | |
dc.contributor.author | Gromada, Jesper | |
dc.date.accessioned | 2019-03-13T13:56:21Z | |
dc.date.available | 2019-03-13T13:56:21Z | |
dc.date.created | 2018-10-09T19:23:56Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Nature Communications. 2018, 9 1-11. | nb_NO |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/11250/2589887 | |
dc.description.abstract | Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We investigate protein-altering variants in ANGPTL4 among 58,124 participants in the DiscovEHR human genetics study, with follow-up studies in 82,766 T2D cases and 498,761 controls. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85–0.92, p = 6.3 × 10−10), lower fasting glucose, and greater insulin sensitivity. Predicted loss-of-function variants are associated with lower odds of T2D among 32,015 cases and 84,006 controls (odds ratio 0.71, 95% confidence interval 0.49–0.99, p = 0.041). Functional studies in Angptl4-deficient mice confirm improved insulin sensitivity and glucose homeostasis. In conclusion, genetic inactivation of ANGPTL4 is associated with improved glucose homeostasis and reduced risk of T2D. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Research | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 1-11 | nb_NO |
dc.source.volume | 9 | nb_NO |
dc.source.journal | Nature Communications | nb_NO |
dc.identifier.doi | 10.1038/s41467-018-04611-z | |
dc.identifier.cristin | 1619179 | |
dc.relation.project | Norges forskningsråd: 248817 | nb_NO |
dc.description.localcode | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |