dc.contributor.author | Helgadottir, Anna | |
dc.contributor.author | Thorleifsson, Gudmar | |
dc.contributor.author | Gretarsdottir, Solveig | |
dc.contributor.author | Stefansson, Olafur A. | |
dc.contributor.author | Tragante, Vinicius | |
dc.contributor.author | Thorolfsdottir, Rosa B. | |
dc.contributor.author | Jonsdottir, Ingileif | |
dc.contributor.author | Bjornsson, Thorsteinn | |
dc.contributor.author | Steinthorsdottir, Valgerdur | |
dc.contributor.author | Verweij, Niek | |
dc.contributor.author | Nielsen, Jonas B. | |
dc.contributor.author | Zhou, Wei | |
dc.contributor.author | Folkersen, Lasse | |
dc.contributor.author | Martinsson, Andreas | |
dc.contributor.author | Heydarpour, Mahyar | |
dc.contributor.author | Prakash, Siddharth | |
dc.contributor.author | Oskarsson, Gylfi | |
dc.contributor.author | Gudbjartsson, Tomas | |
dc.contributor.author | Geirsson, Arnar | |
dc.contributor.author | Olafsson, Isleifur | |
dc.contributor.author | Sigurdsson, Emil L. | |
dc.contributor.author | Almgren, Peter | |
dc.contributor.author | Melander, Olle | |
dc.contributor.author | Franco-Cereceda, Anders | |
dc.contributor.author | Hamsten, Anders | |
dc.contributor.author | Fritsche, Lars | |
dc.contributor.author | Lin, Maoxuan | |
dc.contributor.author | Yang, Bo | |
dc.contributor.author | Hornsby, Whitney | |
dc.contributor.author | Guo, Dongchuan | |
dc.contributor.author | Brummett, Chad M. | |
dc.contributor.author | Abecasis, Goncalo | |
dc.contributor.author | Mathis, Michael | |
dc.contributor.author | Milewicz, Dianna | |
dc.contributor.author | Body, Simon C. | |
dc.contributor.author | Eriksson, Per | |
dc.contributor.author | Willer, Cristen J. | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Newton-Cheh, Christopher | |
dc.contributor.author | Smith, J. Gustav | |
dc.contributor.author | Danielsen, Ragnar | |
dc.contributor.author | Thorgeirsson, Gudmundur | |
dc.contributor.author | Thorsteinsdottir, Unnur | |
dc.contributor.author | Gudbjartsson, Daniel F. | |
dc.contributor.author | Holm, Hilma | |
dc.contributor.author | Stefansson, Kari | |
dc.date.accessioned | 2019-03-04T15:27:15Z | |
dc.date.available | 2019-03-04T15:27:15Z | |
dc.date.created | 2018-11-05T07:16:41Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Nature Communications. 2018, 9 . | nb_NO |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/11250/2588580 | |
dc.description.abstract | Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 controls with a follow-up in up to 4,850 cases and 451,731 controls of European ancestry. We identify two new AS loci, on chromosome 1p21 near PALMD (rs7543130; odds ratio (OR) = 1.20, P = 1.2 × 10−22) and on chromosome 2q22 in TEX41 (rs1830321; OR = 1.15, P = 1.8 × 10−13). Rs7543130 also associates with bicuspid aortic valve (BAV) (OR = 1.28, P = 6.6 × 10−10) and aortic root diameter (P = 1.30 × 10−8), and rs1830321 associates with BAV (OR = 1.12, P = 5.3 × 10−3) and coronary artery disease (OR = 1.05, P = 9.3 × 10−5). The results implicate both cardiac developmental abnormalities and atherosclerosis-like processes in the pathogenesis of AS. We show that several pathways are shared by CAD and AS. Causal analysis suggests that the shared risk factors of Lp(a) and non-high-density lipoprotein cholesterol contribute substantially to the frequent co-occurence of these diseases. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Research | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Genome-wide analysis yields new loci associating with aortic valve stenosis | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.source.pagenumber | 10 | nb_NO |
dc.source.volume | 9 | nb_NO |
dc.source.journal | Nature Communications | nb_NO |
dc.identifier.doi | 10.1038/s41467-018-03252-6 | |
dc.identifier.cristin | 1626847 | |
dc.relation.project | Norges forskningsråd: 248817 | nb_NO |
dc.description.localcode | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |