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dc.contributor.authorWatts, Eleanor L.
dc.contributor.authorAppleby, Paul N.
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorBueno-De-Mesquita, Hendrik Bastiaan
dc.contributor.authorChan, June M.
dc.contributor.authorChen, Chu
dc.contributor.authorCohn, Barbara A.
dc.contributor.authorCook, Michael B.
dc.contributor.authorFlicker, Leon
dc.contributor.authorFreedman, Neal D.
dc.contributor.authorGiles, Graham G.
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGislefoss, Randi Elin
dc.contributor.authorHankey, Graeme J.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKnekt, Paul
dc.contributor.authorKolonel, Laurence N.
dc.contributor.authorKubo, Tatsuhiko
dc.contributor.authorLe Marchand, Loïc
dc.contributor.authorLuben, Robert N.
dc.contributor.authorLuostarinen, Tapio
dc.contributor.authorMännistö, Satu
dc.contributor.authorMetter, E. Jeffrey
dc.contributor.authorMikami, Kazuya
dc.contributor.authorMilne, Roger L.
dc.contributor.authorOzasa, Kotaro
dc.contributor.authorPlatz, Elizabeth A.
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorRissanen, Harri
dc.contributor.authorSawada, Norie
dc.contributor.authorStampfer, Meir
dc.contributor.authorStanczyk, Frank Z.
dc.contributor.authorStattin, Pär
dc.contributor.authorTamakoshi, Akiko
dc.contributor.authorTangen, Catherine M.
dc.contributor.authorThompson, Ian M.
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorUrsin, Giske
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorWeiss, Noel S.
dc.contributor.authorYeap, Bu B.
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorKey, Timothy J.
dc.contributor.authorTravis, Ruth C.
dc.identifier.citationEuropean Urology. 2018, 1-10.nb_NO
dc.description.abstractBackground Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. Objective To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. Design, setting, and participants Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. Outcome measurements and statistical analysis Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. Results and limitations Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR = 0.77, 95% confidence interval [CI] 0.69–0.86; p < 0.001) compared with men with higher concentrations (2nd–10th tenths of the distribution). Heterogeneity was present by tumour grade (phet = 0.01), with a lower risk of low-grade disease (OR = 0.76, 95% CI 0.67–0.88) and a nonsignificantly higher risk of high-grade disease (OR = 1.56, 95% CI 0.95–2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. Conclusions Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. Patient summary In this study, we looked at circulating testosterone levels and risk of developing prostate cancer, finding that men with low testosterone had a lower risk of prostate cancer.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleLow free testosterone and prostate cancer risk: A collaborative analysis of 20 prospective studiesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalEuropean Urologynb_NO
dc.description.localcode© 2018 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY license (
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal