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dc.contributor.authorMarkovitz, Amanda Rose
dc.contributor.authorHaug, Eirin Beate
dc.contributor.authorHorn, Julie
dc.contributor.authorFraser, Abigail
dc.contributor.authorMacdonald-Wallis, Corrie
dc.contributor.authorTilling, Kate
dc.contributor.authorRimm, Eric B
dc.contributor.authorMissmer, Stacey A.
dc.contributor.authorWilliams, Paige
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorRich-Edwards, Janet Wilson
dc.identifier.citationJournal of Lipid Research. 2018, 59 2403-2412.nb_NO
dc.description.abstractWe examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trøndelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline models, we estimated differences in nonfasting lipid levels from before to after first birth in parous women and between parous and nulliparous women. HDL cholesterol (HDL-C) dropped by −4.2 mg/dl (95% CI: −5.0, −3.3) from before to after first birth in adjusted models, a 7% change, and the total cholesterol (TC) to HDL-C ratio increased by 0.18 (95% CI: 0.11, 0.25), with no change in non-HDL-C or triglycerides. Changes in HDL-C and the TC/HDL-C ratio associated with pregnancy persisted for decades, leading to altered life-course lipid trajectories. For example, parous women had a lower HDL-C than nulliparous women at the age of 50 years (−1.4 mg/dl; 95% CI: −2.3, −0.4). Adverse changes in lipids were greatest after first birth, with small changes after subsequent births, and were larger in women who did not breastfeed. Findings suggest that pregnancy is associated with long-lasting adverse changes in HDL-C, potentially setting parous women on a more atherogenic trajectory than prior to pregnancy.nb_NO
dc.publisherAmerican Society for Biochemistry and Molecular Biologynb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleDoes pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway.nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalJournal of Lipid Researchnb_NO
dc.relation.projectNorges forskningsråd: 231149nb_NO
dc.description.localcodeCopyright © 2018 Markovitz et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Author’s Choice—Final version open access under the terms of the Creative Commons CC-BY license.nb_NO
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag

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Navngivelse 4.0 Internasjonal
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