Vis enkel innførsel

dc.contributor.authorWöber, Christian
dc.contributor.authorWöber-Bingöl, Çiçek
dc.contributor.authorUluduz, Derya
dc.contributor.authorAslan, Tuna Stefan
dc.contributor.authorUygunoglu, Uğur
dc.contributor.authorTüfekçi, Ahmet
dc.contributor.authorAlp, Selen Ilhan
dc.contributor.authorDuman, Taşkın
dc.contributor.authorSürgün, Fidan
dc.contributor.authorEmir, Gülser Karadaban
dc.contributor.authorDemir, Caner Feyzi
dc.contributor.authorBalgetir, Ferhat
dc.contributor.authorÖzdemir, Yeliz Bahar
dc.contributor.authorAuer, Tanja
dc.contributor.authorSiva, Aksel
dc.contributor.authorSteiner, Timothy J.
dc.identifier.citationThe Journal of Headache and Pain. 2018, 19:18 1-9.nb_NO
dc.description.abstractBackground Headache is a leading disabler in adults worldwide. In children and adolescents, the same may be true but the evidence is much poorer. It is notable that published epidemiological studies of these age groups have largely ignored headaches not fulfilling any specific set of ICHD criteria, although such headaches appear to be common. A new approach to these is needed: here we introduce, and investigate, a diagnostic category termed “undifferentiated headache” (UdH), defined in young people as recurrent mild-intensity headache of < 1 h’s duration. Methods We conducted a nationwide cross-sectional survey in 31 schools in six regions of Turkey selected by mixed convenience-based and purposive modified cluster-sampling. A validated, standardised self-completed structured questionnaire was administered by a physician-investigator to entire classes of pupils aged 6–17 years. Results Of the identified sample of 7889 pupils, 7088 (89.8%) participated. The 1-year prevalence of UdH was 29.2%, of migraine (definite and probable) 26.7%, and of tension-type headache (TTH) (definite and probable) 12.9%. UdH differed with respect to almost all headache features and associated symptoms from both migraine and TTH. Burden of headache and use of acute medication were lower in UdH than in migraine and TTH. Headache yesterday was less common in UdH than migraine (OR 0.32; 95% CI 0.28–0.37) and TTH (OR 0.64; 95% CI 0.56–0.77). Quality of life (QoL) was better in UdH (33.6 ± 5.2) than in migraine (30.3 ± 5.6; p < 0.001) and TTH (32.4 ± 5.3; p < 0.001), but worse than in pupils without headache (35.7 ± 4.7; p < 0.001). Conclusions This large nationwide study in Turkey of pupils aged 6–17 years has shown that many children and adolescents have a headache type that does not conform to existing accepted diagnostic criteria. This new diagnostic category of presumably still-evolving headache (undifferentiated headache) is common. UdH differs in almost all measurable respects from both migraine and TTH. Although characterised by mild headaches lasting < 1 h, UdH is associated with significant adverse impact on QoL. Longitudinal cohort studies are needed to evaluate the prognosis of UdH but, meanwhile, recognition of UdH and its distinction from migraine and TTH has implications for epidemiological studies, public-health policy and routine clinical practice.nb_NO
dc.publisherSpringer Opennb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleUndifferentiated headache: broadening the approach to headache in children and adolescents, with supporting evidence from a nationwide school-based cross-sectional survey in Turkeynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalThe Journal of Headache and Painnb_NO
dc.description.localcode© The Author(s). 2018 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.nb_NO
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap

Tilhørende fil(er)


Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal