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dc.contributor.authorNymo, Siren
dc.contributor.authorCoutinho, Silvia dos Santos Ribeiro F
dc.contributor.authorTorgersen, Linn-Christin H.
dc.contributor.authorBomo, Ola Jakob
dc.contributor.authorHaugvaldstad, Ingrid
dc.contributor.authorTruby, Helen
dc.contributor.authorKulseng, Bård Eirik
dc.contributor.authorMartins, Catia
dc.identifier.citationBritish Journal of Nutrition. 2018, 120 (2), 141-149.nb_NO
dc.description.abstractDiet-induced weight loss (WL) is associated with reduced resting and non-resting energy expenditure (EE), driven not only by changes in body composition but also potentially by adaptive thermogenesis (AT). When exactly this happens, during progressive WL, remains unknown. The aim of this study was to determine the timeline of changes in RMR and exercise-induced EE (EIEE), stemming from changes in body composition v. the presence of AT, during WL with a very-low-energy diet (VLED). In all, thirty-one adults (eighteen men) with obesity (BMI: 37 (sem 4·5) kg/m2; age: 43 (sem 10) years) underwent 8 weeks of a VLED, followed by 4 weeks of weight maintenance. Body weight and composition, RMR, net EIEE (10, 25 and 50 W) and AT (for RMR (ATRMR) and EIEE (ATEIEE)) were measured at baseline, day 3 (2 (sem 1) % WL), after 5 and 10 % WL and at weeks 9 (16 (sem 2) %) and 13 (16 (sem 1) %). RMR and fat mass were significantly reduced for the first time at 5 % WL (12 (sem 8) d) (P<0·01 and P<0·001, respectively) and EIEE at 10 % WL (32 (sem 8) d), for all levels of power (P<0·05), and sustained up to week 13. ATRMR was transiently present at 10 % WL (−460 (sem 690) kJ/d, P<0·01). A fall in RMR should be anticipated at ≥5 % WL and a reduction in EIEE at ≥10 % WL. Transient ATRMR can be expected at 10 % WL. These physiological adaptations may make progressive WL difficult and will probably contribute to relapse.nb_NO
dc.publisherNutrition Societynb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleTimeline of changes in adaptive physiological responses, at the level of energy expenditure, with progressive weight lossnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalBritish Journal of Nutritionnb_NO
dc.description.localcodeThis is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameFakultet for medisin og helsevitenskap

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal